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Comparison of oral recombinant erythropoietin and subcutaneous recombinant erythropoietin in prevention of anemia of prematurity
Joint Authors
Gholami, M.
Saeidi, R.
Bani Hashim, A.
Hammoud, M.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 14, Issue 3 (31 Mar. 2012), pp.178-181, 4 p.
Publisher
Publication Date
2012-03-31
Country of Publication
United Arab Emirates
No. of Pages
4
Main Subjects
Topics
Abstract EN
Background: Premature neonates are at risk for severe anemia and erythropoietin is the most important hormone in erythropoiesis.
The aim of this study was to evaluate the influence of oral recombinant human erythropoietin (rhEPO) in proving erythropoiesis in neonates.
Methods: This was a randomized clinical trial study.
Thirty neonates were enrolled from September 2007 to September 2008.
The first group received oral rhEPO and Fe and the second, subcutaneous rhEPO and Fe.
The patients’ Hb, HCT and the need to blood transfusion were recorded.
We included all infants with gestational age <34 weeks, birth weight <1500 gr, without respiratory distress (O2 Saturation> 85%, FiO2 of 30%), full feeding tolerance so that oral Fe can be administrated.
Results: In first group (oral=PO), 65% of neonates were female and 35% were male, mean weight was 1140 g and mean GA was 32.6 weeks.
In the second group (subcutaneous=SC), 42% were female and 58% were male.
The mean weight was 1245 g and mean GA was 31.2 weeks and this was not statistically significant.
In the first group, the mean Hb and HCT were 9.7±1.9 and 29.6±5.9 g/dl.
In the second group, the figures were 12.5±1.7 and 38.8±5.1 which were statistically significant.
There was no difference in the weight gain between two groups.
In the first group, 3 neonates (20%) and in the second one, 1 neonate (15%) needed blood transfusion.
Conclusions: rhEPO administration either PO or SC could prevent anemia of prematurity but SC rout was more effective.
American Psychological Association (APA)
Saeidi, R.& Bani Hashim, A.& Hammoud, M.& Gholami, M.. 2012. Comparison of oral recombinant erythropoietin and subcutaneous recombinant erythropoietin in prevention of anemia of prematurity. Iranian Red Crescent Medical Journal،Vol. 14, no. 3, pp.178-181.
https://search.emarefa.net/detail/BIM-311748
Modern Language Association (MLA)
Saeidi, R.…[et al.]. Comparison of oral recombinant erythropoietin and subcutaneous recombinant erythropoietin in prevention of anemia of prematurity. Iranian Red Crescent Medical Journal Vol. 14, no. 3 (Mar. 2012), pp.178-181.
https://search.emarefa.net/detail/BIM-311748
American Medical Association (AMA)
Saeidi, R.& Bani Hashim, A.& Hammoud, M.& Gholami, M.. Comparison of oral recombinant erythropoietin and subcutaneous recombinant erythropoietin in prevention of anemia of prematurity. Iranian Red Crescent Medical Journal. 2012. Vol. 14, no. 3, pp.178-181.
https://search.emarefa.net/detail/BIM-311748
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 181
Record ID
BIM-311748