Thioacetamide-induced acute hepatic encephalopathy in rat : behavioral, biochemical and histological changes
Joint Authors
Tanidih, N.
Mihrabani, D.
Imanieh, M. H.
Farjam, M.
Dehdab, S.
Abbassnia, F.
Pakbaz, S.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 14, Issue 3 (31 Mar. 2012), pp.164-170, 7 p.
Publisher
Publication Date
2012-03-31
Country of Publication
United Arab Emirates
No. of Pages
7
Main Subjects
Abstract EN
Background: As a serious neuropsychiatric disease, hepatic encephalopathy (HE) is a clinical condition with several types regarding chronicity and clinical diversity that can develop as a complication of both acute and chronic liver failure.
This study evaluates changes in thioacetamide (TAA)-induced acute hepatic encephalopathy (AHE) in rat as an animal model.
Methods: Both genders of C57BL6, BALB/C mice and Sprague Dawley rats; (10 animals in each group) were compared for induction of AHE to clarify which animal and gender were appropriate.
The animals (10 male rats in each group) were categorized in 4 groups according to the dose of the TAA administered (200, 300 and 400 mg/kg of TAA at 24 h intervals for 4 days).
A control group was treated with solvent of TAA which was water (5 ml/kg/day).
The behavioral, biochemical markers of hepatic failure and histological aspects of thioacetamide (TAA) induced AHE and the correlation between the clinical severity and liver failure biomarkers were evaluated.
Results: Rat was shown to be an animal model of choice for AHE while the optimum dosage of TAA to induce AHE was 300 mg/kg/day at 24 h intervals for 4 days.
The behavioral score was partially correlated with the rising of some biomarkers and pathological findings.
Conclusion: Rat can be introduced as the animal of choice for AHE to study the pathophysiology, pharmacology and the survival rate of disease in liver transplant patients.
American Psychological Association (APA)
Farjam, M.& Dehdab, S.& Abbassnia, F.& Mihrabani, D.& Tanidih, N.& Pakbaz, S.…[et al.]. 2012. Thioacetamide-induced acute hepatic encephalopathy in rat : behavioral, biochemical and histological changes. Iranian Red Crescent Medical Journal،Vol. 14, no. 3, pp.164-170.
https://search.emarefa.net/detail/BIM-311762
Modern Language Association (MLA)
Farjam, M.…[et al.]. Thioacetamide-induced acute hepatic encephalopathy in rat : behavioral, biochemical and histological changes. Iranian Red Crescent Medical Journal Vol. 14, no. 3 (Mar. 2012), pp.164-170.
https://search.emarefa.net/detail/BIM-311762
American Medical Association (AMA)
Farjam, M.& Dehdab, S.& Abbassnia, F.& Mihrabani, D.& Tanidih, N.& Pakbaz, S.…[et al.]. Thioacetamide-induced acute hepatic encephalopathy in rat : behavioral, biochemical and histological changes. Iranian Red Crescent Medical Journal. 2012. Vol. 14, no. 3, pp.164-170.
https://search.emarefa.net/detail/BIM-311762
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 169-170
Record ID
BIM-311762