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Serum level of matrix metalloproteinase-3 in patients with oral lichen planus
Joint Authors
Haydari, S. T.
Rezaee, M.
Tadbir, A. Andisheh
Farzin, M.
Mardani, M.
Fattahi, M. J.
Ghabanchi, J.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 14, Issue 1 (31 Jan. 2012), pp.10-13, 4 p.
Publisher
Publication Date
2012-01-31
Country of Publication
United Arab Emirates
No. of Pages
4
Main Subjects
Topics
Abstract EN
Background : Oral Lichen planus (OLP) is a chronic lesion of the oral mucosa with unknown origin.
Basement membrane changes are common in OLP and may be mediated by proteases such as matrix metalloproteinase (MMPs) and mast cell chymase.
The aim of our study was to evaluate the level of serum MMP-3 in OLP compared to normal individuals and assess its clinical significance.
Methods : Thirty four serum samples from patients diagnosed with OLP (12 males, 22 females, age: 42.2 ± 10.8 years) and 34 serum samples from healthy control subjects (11 males, 23 females, age: 42.5 ± 13.3 years) were collected and MMP-3 concentration was measured by ELISA.
Results : The serum MMP-3 level in OLP patients was higher (21.64±24.31 ng/ml) compared with healthy controls (23.63 ± 16.52 ng / ml), but showed no statistically significant difference.
A statistically significant difference was demonstrated between the two types of OLP, being more pronounced in the erosive / atrophic form 6).
Conclusion: The different clinical appearances of OLP are associated with significant differences in MMP-3 serum level.
American Psychological Association (APA)
Farzin, M.& Mardani, M.& Ghabanchi, J.& Fattahi, M. J.& Rezaee, M.& Haydari, S. T.…[et al.]. 2012. Serum level of matrix metalloproteinase-3 in patients with oral lichen planus. Iranian Red Crescent Medical Journal،Vol. 14, no. 1, pp.10-13.
https://search.emarefa.net/detail/BIM-311800
Modern Language Association (MLA)
Farzin, M.…[et al.]. Serum level of matrix metalloproteinase-3 in patients with oral lichen planus. Iranian Red Crescent Medical Journal Vol. 14, no. 1 (Jan. 2012), pp.10-13.
https://search.emarefa.net/detail/BIM-311800
American Medical Association (AMA)
Farzin, M.& Mardani, M.& Ghabanchi, J.& Fattahi, M. J.& Rezaee, M.& Haydari, S. T.…[et al.]. Serum level of matrix metalloproteinase-3 in patients with oral lichen planus. Iranian Red Crescent Medical Journal. 2012. Vol. 14, no. 1, pp.10-13.
https://search.emarefa.net/detail/BIM-311800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 12-13
Record ID
BIM-311800