Hypofractionated conformal irradiation of patients with malignant glioma
Joint Authors
Abu Ziyadah, Muhammad Abd al-Hamid
Abu Kresha, Ahmad E.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 24, Issue 3 (30 Sep. 2012), pp.139-143, 5 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2012-09-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Purpose : The aim of the study is to evaluate the effect of a conformal irradiation in short fractionation scheme of 49.5 Gy in 15 fractions in an overall time of 3 weeks, in terms of overall survival (OAS) and progression free survival (PFS) rates in brain glioma patients.
Patients and methods : A prospective study was conducted on 54 brain glioma patients and was carried out in the Radiation Oncology Department, South Egypt Cancer Institute, Assiut University during the period from April 2006 till June 2009.
Patients were treated by hypofractionated conformal irradiation (49.5 Gy / 15 fractions / 3 weeks).
Results : The median follow up was 23 months (range : 9–39 months).
Two-year OAS and PFS rates were 68 % and 60 %, respectively.
In univariate analysis, age > 50 years, poor performance status [Karnofasky score of P40–670 %], poor neuroperformance status of score III, high-grade tumor [glioblastoma multiforme], and biopsy were all associated with statistically significant reduction in OAS and PFS rates.
Multivariate analysis, showed that age >50 years and glioblastoma pathology were the only independent prognostic factors that were associated with poor OAS (p = 0.003 and p = 0.004, respectively), and PFS (p = 0.027 and p = 0.011, respectively).
Conclusion : Hypofractionated conformal radiotherapy was as effective as the conventional radiotherapy, with time sparing for patients, and for radiation oncology centers.
Hypofractionated radiotherapy may be considered the radiotherapy regimen of choice in clinical practice for patients with gliomas.
American Psychological Association (APA)
Abu Ziyadah, Muhammad Abd al-Hamid& Abu Kresha, Ahmad E.. 2012. Hypofractionated conformal irradiation of patients with malignant glioma. Journal of the Egyptian National Cancer Institute،Vol. 24, no. 3, pp.139-143.
https://search.emarefa.net/detail/BIM-312749
Modern Language Association (MLA)
Abu Ziyadah, Muhammad Abd al-Hamid& Abu Kresha, Ahmad E.. Hypofractionated conformal irradiation of patients with malignant glioma. Journal of the Egyptian National Cancer Institute Vol. 24, no. 3 (Sep. 2012), pp.139-143.
https://search.emarefa.net/detail/BIM-312749
American Medical Association (AMA)
Abu Ziyadah, Muhammad Abd al-Hamid& Abu Kresha, Ahmad E.. Hypofractionated conformal irradiation of patients with malignant glioma. Journal of the Egyptian National Cancer Institute. 2012. Vol. 24, no. 3, pp.139-143.
https://search.emarefa.net/detail/BIM-312749
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 143
Record ID
BIM-312749