Evaluation of c-kit expression in classic kaposi’s sarcoma in a cohort of Egyptian patients
Joint Authors
Husayn, Tariq M.
al-Sabaa, Basma M.
Hanafi, Nisrin F.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 24, Issue 1 (31 Mar. 2012), pp.1-6, 6 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2012-03-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : kaposi’s sarcoma (KS) is an angioproliferative disorder associated with human herpes virus 8 infection.
Classic KS is the most prevalent type of KS in countries of the Mediterranean basin including Egypt.
Several in vitro studies have detected c-kit expression in AIDS related-KS however, only a few studies addressed this issue in the classic type with no data on the ethnicity of studied cases.
The prospect of installing targeted anti- c-kit treatment to KS patients presents a promising avenue in KS therapeutics.
Aim : to elucidate the expression of c-kit in classic KS cases and study possible relations with expression of HHV8 latency-associated nuclear antigen-1 (LANA-1) and other clinic pathological parameters.
Methods : Twenty four cases of classic KS of the plaque and nodular stages in the lower limb were studied.
Immunohistochemical detection of HHV8-LANA-1 and c-kit was carried out on archival paraffin embedded tissue, possession of the Pathology and Dermatology Departments, Alexandria School Of Medicine, Egypt.
Statistical analysis of possible relations between both antigens and clinic pathological parameters (patient’s age and gender and histological stage) was performed.
Results : HHV8 expression was detected in 100% of cases while c-kit immunoreactivity was found in 54.2 % of cases.
There was no correlation between c-kit and HHV8 immunoreactivity or any of the studied clinic pathological parameters.
Conclusions : this is the first report of c-kit expression in classic KS in an ethnically homogeneous cohort of Arabs of the Mediterranean region.
We detected c-kit expression in about half the cases with no relationship to HHV8 LANA expression or clinic pathological parameters.
American Psychological Association (APA)
Husayn, Tariq M.& al-Sabaa, Basma M.& Hanafi, Nisrin F.. 2012. Evaluation of c-kit expression in classic kaposi’s sarcoma in a cohort of Egyptian patients. Journal of the Egyptian National Cancer Institute،Vol. 24, no. 1, pp.1-6.
https://search.emarefa.net/detail/BIM-312821
Modern Language Association (MLA)
Husayn, Tariq M.…[et al.]. Evaluation of c-kit expression in classic kaposi’s sarcoma in a cohort of Egyptian patients. Journal of the Egyptian National Cancer Institute Vol. 24, no. 1 (Mar. 2012), pp.1-6.
https://search.emarefa.net/detail/BIM-312821
American Medical Association (AMA)
Husayn, Tariq M.& al-Sabaa, Basma M.& Hanafi, Nisrin F.. Evaluation of c-kit expression in classic kaposi’s sarcoma in a cohort of Egyptian patients. Journal of the Egyptian National Cancer Institute. 2012. Vol. 24, no. 1, pp.1-6.
https://search.emarefa.net/detail/BIM-312821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6
Record ID
BIM-312821