Role of ascitic fluid C3 in spontaneous bacterial peritonitis
Joint Authors
Kamal, Amani Talat
Osman, Iman Najib
Shahin, Rasha Yusuf
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 13, Issue 1 (30 Apr. 2012), pp.81-85, 5 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2012-04-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : the C3 component of complement tends to be reduced in cirrhosis and patients with reduced ascitic fluid C3 concentration and reduced opsonic activities have been shown to be predisposed to SBP [1].
Aim of the work : to compare the level of ascitic fluid C3 concentration in cirrhotic patients with and without spontaneous bacterial peritonitis to determine its possible protective role against acquiring infection.
Methods : this is a prospective case-control study in which we recruited 45 cirrhotic patients presenting with ascites, of which 25 showed evidence of SBP.
All patients had diagnostic paracentesis, received the appropriate treatment, discharged and followed-up monthly for 3 months, with ascitic fluid C3 measurement.
Ascitic fluid C3 was compared between both groups at baseline and for three successive reading over 3 months.
It was also compared in the same patients group over this interval and correlated with other AF parameters at baseline reading.
Conclusion : Ascitic fluid C3 is reduced in cirrhotic patients with SBP and stays lower compared with those without the infection after the first episode.
So we conclude that C3 plays an important role in the local defense of ascitic fluid and needs further long term follow-up studies to evaluate its role as a predictor of prognosis for cirrhotic ascitic patients.
American Psychological Association (APA)
Kamal, Amani Talat& Osman, Iman Najib& Shahin, Rasha Yusuf. 2012. Role of ascitic fluid C3 in spontaneous bacterial peritonitis. The Egyptian Journal of Medical Human Genetics،Vol. 13, no. 1, pp.81-85.
https://search.emarefa.net/detail/BIM-312927
Modern Language Association (MLA)
Kamal, Amani Talat…[et al.]. Role of ascitic fluid C3 in spontaneous bacterial peritonitis. The Egyptian Journal of Medical Human Genetics Vol. 13, no. 1 (2012), pp.81-85.
https://search.emarefa.net/detail/BIM-312927
American Medical Association (AMA)
Kamal, Amani Talat& Osman, Iman Najib& Shahin, Rasha Yusuf. Role of ascitic fluid C3 in spontaneous bacterial peritonitis. The Egyptian Journal of Medical Human Genetics. 2012. Vol. 13, no. 1, pp.81-85.
https://search.emarefa.net/detail/BIM-312927
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 85
Record ID
BIM-312927