![](/images/graphics-bg.png)
Haemophilia a patients are not at increased risk of hepatitis a virus infection : an Egyptian experience
Joint Authors
al-Gohary, Iman A. M.
al-Ghani, Shirin M. A.
al-Hadari, Shirin F.
Tantawi, Azzah A. G.
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 13, Issue 1 (30 Apr. 2012), pp.93-97, 5 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2012-04-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Hepatitis A virus (HAV) infection is endemic in Egypt.
Hemophiliacs are at risk of transmission through exposure to blood products.
We evaluated the seroprevalence of hepatitis A in Egyptian patients with haemophilia A as well as the safety and immunogenicity of subcutaneous hepatitis A vaccine in hemophiliacs'.
Methods : 182 male children and adolescents were studied (82 patients with moderate and severe haemophilia A and 100 healthy controls).
Screening for anti-HAV antibody was done and seronegative subjects received hepatitis A vaccine (Havri at a dose of 720 Elisa Units at 0 and 6 months, given subcutaneously in hemophiliacs' and intramuscularly for controls.
Seroconversion was assessed 2 months after the second vaccine dose by anti-HAV IgG.
Results : seroprevalence of HAV antibodies was 87.6 % among hemophiliacs and 90 % among the control group.
Seronegative children (mean age 4.4 ± 3.71 years) were significantly younger than seropositive children (mean age 10.2 ± 3.86 years).
Hepatitis A vaccine was given to 10 non immune haemophilia patients and 10 controls.
The vaccine was well tolerated with local side effects including pain in 40 % and erythema in 20 % of hemophiliacs' versus 20 % for pain and erythema in the control group.
All patients and controls developed seroconversion 2 months after the second dose ; with no significant difference as regards the titre of anti-HAV IgG (351.4 ± 65.0 IU / L for hemophiliacs and 367.0 ± 132.3 IU / L for controls Conclusion : HAV infection occurs early in life in Egyptian children, necessitating hepatitis A vaccination in early life.
The vaccine is safe and effective when given subcutaneous in hemophiliacs'.
American Psychological Association (APA)
Tantawi, Azzah A. G.& al-Gohary, Iman A. M.& al-Ghani, Shirin M. A.& al-Hadari, Shirin F.. 2012. Haemophilia a patients are not at increased risk of hepatitis a virus infection : an Egyptian experience. The Egyptian Journal of Medical Human Genetics،Vol. 13, no. 1, pp.93-97.
https://search.emarefa.net/detail/BIM-312932
Modern Language Association (MLA)
Tantawi, Azzah A. G.…[et al.]. Haemophilia a patients are not at increased risk of hepatitis a virus infection : an Egyptian experience. The Egyptian Journal of Medical Human Genetics Vol. 13, no. 1 (2012), pp.93-97.
https://search.emarefa.net/detail/BIM-312932
American Medical Association (AMA)
Tantawi, Azzah A. G.& al-Gohary, Iman A. M.& al-Ghani, Shirin M. A.& al-Hadari, Shirin F.. Haemophilia a patients are not at increased risk of hepatitis a virus infection : an Egyptian experience. The Egyptian Journal of Medical Human Genetics. 2012. Vol. 13, no. 1, pp.93-97.
https://search.emarefa.net/detail/BIM-312932
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 97
Record ID
BIM-312932