Interleukin 6 (IL6) as a predictor outcome in patients with compensated cirrhosis and symptomatic gall stones after cholecystectomy
Joint Authors
Hijazi, Asmaa
Rajab, Ilham
Murshid, Masad
al-Wadi, Salih
Khafaji, Wael
Moatamed, Ahmad
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 13, Issue 2 (31 Aug. 2012), pp.189-195, 7 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2012-08-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Compensated cirrhosis means that the liver is heavily scarred but can still perform many important functions; many peoples with compensated cirrhosis have gall bladder stones.
The advantages of laparoscopic cholecystectomy (LC) for most patients have been extensively published.
However its benefits and successful use in patients with cirrhosis are less documented.
The study compromised 50 patients with symptomatic gallstone in compensated liver disease and undergone either open cholecystectomy (OC) or laparoscopic cholecystectomy.
These patients were randomized into two groups: Group I included 24 patients who underwent OC, and group II included 26 patients who underwent LC.
Patient’s age, sex, clinical presentation and Child-Turcotte-Pugh (CTP) class were documented.
No patients in this study had CTP class c cirrhosis.
IL-6 was measured by ELISA, postoperative pain (measured by Visual analog scale), hospital stay, blood loss, recovery time (return to work), and liver function tests were documented.
IL-6 was significantly lowered at 6th hour and 12th hour post-operative in LC group.
Mean surgical time was significantly longer in OC than LC group, (mean ±SD, 96.6 ±32 vs 58.7 ± 23.8 min, P = 0.037).
No patients in group II required any blood replacement in contrast to 9 patients (37.5 %) in group I.
Intraoperative bleeding remained significantly higher in group I (P = 0.043).
No patients in group II had wound complications compared with 5 patients (29.14 %) in group I.
Group I had significantly longer hospital stay than group II, mean 9.0+ 1.3 days (median 7) vs 2.3 days +1.9 median 2.5) ; P = 0.001) Our results were demonstrated that laparoscopic cholecystectomy can be performed safely in patients with CTP class A and B cirrhosis.
IL-6 was more significantly, increased post operatively in open cholecystectomy than laparoscopic one and it correlated well with intensity of operative trauma.
American Psychological Association (APA)
Rajab, Ilham& Hijazi, Asmaa& Murshid, Masad& al-Wadi, Salih& Khafaji, Wael& Moatamed, Ahmad. 2012. Interleukin 6 (IL6) as a predictor outcome in patients with compensated cirrhosis and symptomatic gall stones after cholecystectomy. The Egyptian Journal of Medical Human Genetics،Vol. 13, no. 2, pp.189-195.
https://search.emarefa.net/detail/BIM-312997
Modern Language Association (MLA)
Rajab, Ilham…[et al.]. Interleukin 6 (IL6) as a predictor outcome in patients with compensated cirrhosis and symptomatic gall stones after cholecystectomy. The Egyptian Journal of Medical Human Genetics Vol. 13, no. 2 (2012), pp.189-195.
https://search.emarefa.net/detail/BIM-312997
American Medical Association (AMA)
Rajab, Ilham& Hijazi, Asmaa& Murshid, Masad& al-Wadi, Salih& Khafaji, Wael& Moatamed, Ahmad. Interleukin 6 (IL6) as a predictor outcome in patients with compensated cirrhosis and symptomatic gall stones after cholecystectomy. The Egyptian Journal of Medical Human Genetics. 2012. Vol. 13, no. 2, pp.189-195.
https://search.emarefa.net/detail/BIM-312997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 194-195
Record ID
BIM-312997