Thalassemia intermedia : an overview
Joint Authors
Shawqi, Rabah M.
Kamal, Tariq M.
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 13, Issue 3 (31 Dec. 2012), pp.245-255, 11 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2012-12-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Topics
Abstract EN
B-Thalassemia is considered the most common chronic hemolytic anemia in Egypt.
Patients with b-thalassemia whose anemia is not so severe as to necessitate regular transfusions are said to have thalassemia intermedia.
It is characterized by a significant genetic and clinical heterogeneity.
The clinical phenotype ranges between the severe, transfusion-dependent thalassemia major and the asymptomatic carrier state.
Thalassemia intermedia represents up to one-fourth of b-thalassemia patients.
It is essential to discuss the reasons for the remarkable heterogeneity and natural history of thalassemia intermedia so that an effective method for the control and management of thalassemia intermedia can be established.
This review will outline the genetics of hemoglobin biosynthesis as well as an overview on the pathogenesis, molecular basis, hematologic and clinical features of thalassemia intermedia, in addition to management of complications affecting patients with such disorder.
American Psychological Association (APA)
Shawqi, Rabah M.& Kamal, Tariq M.. 2012. Thalassemia intermedia : an overview. The Egyptian Journal of Medical Human Genetics،Vol. 13, no. 3, pp.245-255.
https://search.emarefa.net/detail/BIM-313001
Modern Language Association (MLA)
Shawqi, Rabah M.& Kamal, Tariq M.. Thalassemia intermedia : an overview. The Egyptian Journal of Medical Human Genetics Vol. 13, no. 3 (2012), pp.245-255.
https://search.emarefa.net/detail/BIM-313001
American Medical Association (AMA)
Shawqi, Rabah M.& Kamal, Tariq M.. Thalassemia intermedia : an overview. The Egyptian Journal of Medical Human Genetics. 2012. Vol. 13, no. 3, pp.245-255.
https://search.emarefa.net/detail/BIM-313001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 252-255
Record ID
BIM-313001