Genotoxic damage in cultured human peripheral blood lymphocytes of oral contraceptive users
Joint Authors
Afzal, Muhammad
Naz, Falaq
Jyoti, Smita
Akhtar, Nashat
Sadiq, Yasir Hasan
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 13, Issue 3 (31 Dec. 2012), pp.301-305, 5 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2012-12-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Synthetic progestin's and estrogens have been reported to be toxic in various experimental models.
Their prolonged use has been reported to induce cancer in humans.
In the present study the effects of oral contraceptives were studied among users using chromosomal aberrations, sister chromatid exchanges and DNA damage as a parameter, in cultured human peripheral blood lymphocytes.
The study was performed on 25 women (users) and 25 age match controls.
No significant difference was observed in chromosomal aberrations and DNA damage.
A significant increase was observed in sister chromatid exchanges (SCEs) Cell among users.
The results obtained and the risk of oral contraceptives (OCs) nontoxicity has been discussed.
American Psychological Association (APA)
Naz, Falaq& Jyoti, Smita& Akhtar, Nashat& Afzal, Muhammad& Sadiq, Yasir Hasan. 2012. Genotoxic damage in cultured human peripheral blood lymphocytes of oral contraceptive users. The Egyptian Journal of Medical Human Genetics،Vol. 13, no. 3, pp.301-305.
https://search.emarefa.net/detail/BIM-313045
Modern Language Association (MLA)
Naz, Falaq…[et al.]. Genotoxic damage in cultured human peripheral blood lymphocytes of oral contraceptive users. The Egyptian Journal of Medical Human Genetics Vol. 13, no. 3 (2012), pp.301-305.
https://search.emarefa.net/detail/BIM-313045
American Medical Association (AMA)
Naz, Falaq& Jyoti, Smita& Akhtar, Nashat& Afzal, Muhammad& Sadiq, Yasir Hasan. Genotoxic damage in cultured human peripheral blood lymphocytes of oral contraceptive users. The Egyptian Journal of Medical Human Genetics. 2012. Vol. 13, no. 3, pp.301-305.
https://search.emarefa.net/detail/BIM-313045
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 304-305
Record ID
BIM-313045
