Study of some immunological parameters in breast cancer patients in Erbil City

Other Title(s)

دراسة بعض المعايير المناعية لدى مرضى سرطان الثدي في مدينة أربيل

Dissertant

Aziz, Sarhang Hasan

Thesis advisor

Darogha, Suhaylah Nafi Rafiq

University

Salahaddin University-Hawler

Faculty

College of Science

Department

Biology Department

University Country

Iraq

Degree

Master

Degree Date

2012

English Abstract

This study was carried out in Rizgary and Hawler Teaching hospital in Erbil city, from the period of August 2010 to June 2011.

A total of 115 women patients with breast tumor (55 malignant and 60 benign) and 40 females as a control group.

Some immunological parameters were determined in patients a control group.

Results indicated obvious relation between risk factor and breast cancer (BC), among these factors is the age; the most frequent age for breast cancer was that at age group (38- 47) Percentage of patients starting age menarche after 12 year was higher when compared with patients starting at or before 12 year.

The results showed higher percentage of BC in patients who have regularity menses when compared with irregular menstrual cycle.

Also the result showed that the percentage of patients who married after 18 years and more was higher when compared with patients married before 18 years.

Age of first pregnancy in 20 years and greater which was higher than other group.

The results indicated that the percentage of BBD patients who diagnosed premenopausal was higher than postmenopausal and no relation was found in this study between BC and abortion.

Higher percentage of breast feeding found in BC patients when compared with bottle feeding.

Oral contraceptive pills users occupied higher percentage in patients.

Patients which not used hormone replacement therapy (HRT) has higher percentage when compared with patients used HRT.

About half of the patients recorded positive family history.

The numbers of patients diagnosed as stage third and fourth were higher compared with those stage two, unknown and first stage.

According to the of benign breast disease, the unknown cause showed higher percentage when compared with other type.

Number of patients with Body Mass Index (BMI > 25 kg / m2) was higher when compared with number of patients having BMI = 20.

24.9 and < 20 respectively The study showed, there was a marked increase in the total mean of WBC count, granulocytes, lymphocytes and monocytes in breast cancer and benign breast disease when compared with control group (P ≤ 0.05) There were a significant increase in the concentrations of all the immunological parameters (IL- 6, IL- 8, IFN- γ, CA15- 3, ADA activity, IgG, IgM, IgA, C3 and C4) in patients in comparison with the control group.

The highest significant concentration of IL- 6, IL- 8 and IFN- γ were in age interval 18-27 years in BC and BBD group, whereas the lowest significant concentration of IL- 6 was in age interval 48- 57 years, while for IL- 8 and IFN- γ were in age interval 58 and older when compared with control group.

The highest mean level of CA 15-3 and ADA activity was found in 18- 27 and 28- 37 age intervals respectively and lowest level was found in 58 and older, with significant increase in BC and BBD patients.

The concentration of C3 and C4 were increased significantly in BC and BBD patients when compared with control group, and the highest mean level of C3 and C4 was found in 18- 27 years age intervals while the lowest mean level was found in 58 and older.

Higher level of IgG, IgM and IgA was found in 38-47, 18-27 and 28- 37 age intervals respectively and the lowest was found in 58 and older, with significant increase in BC and BBD patients.

Main Subjects

Biology
Medicine

Topics

• Patients
• Cancer
• Iraq
• Irbil
• Breast

No. of Pages

101

Table of Contents

• APA
• MLA
• AMA

Language

English

Data Type

Arab Theses

Record ID

BIM-314561