Synthesis and preliminary antimicrobial study of 2-amino-5-mercapto-1,3,4-thiadiazole derivatives

Abstract EN

Nitrogen heterocycles are of a special interest because they constitute an important class of natural and non natural products, many of which exhibit useful biological activities.

Among these nitrogen heterocycles are 1, 3, 4-thiadiazole containing compounds.

The therapeutic effects of these derivatives have been well studied for a number of pathological conditions including inflammation, pain, or hypertension.

Moreover, synthesis of thiadiazoles has attracted wide-spread attention due to their diverse applications as antibacterial, anticancer, antifungal anti-inflammatory and antidepressant agents.

According to this information’s new derivatives of 1, 3, 4-thiadiazole were designed and synthesized and in the hope of having some activities as antibacterial and antifungal.

These are : • 4-(((5-mercapto-1, 3, 4-thiadiazol-2-yl)imino)methyl)-2-methoxyphenol. • Tert-butyl (1- ((2- ((5- (methylsulfonyl) -1, 3, 4- thiadiazol-2-yl) amino) -2- oxoethyl) amino)-1-oxopropan - 2-yl) carbamate.