Azithomycin as an adjunctive to non-surgical treatment in comparison with doxycycline in chronic periodontitis patients : 2-months randomized clinical trial

Abstract EN

Background : Antibiotic therapy can be used in very specific periodontal treatment situations such as in refractory cases of periodontal disease which is found to be more prevalent in smokers.

The aim of study was to asses the clinical effect of systemic use of Azithromycin and Doxycycline as adjunctive to non surgical scaling and root planning in patients with chronic periodontitis. Materials and methods : The study participants were 21 adult male, divided to three groups.

1n : GI treated by non surgical root planning with systemic intake of Azithromycin of 500 mg once daily for three days only.

In GII Doxycycline 100mg once daily was given for one week in addition to non surgical root planning while in the G III (control group) the patients were treated only by a routine scaling and root planning with out using any type of drug.

The periodontal parameters used are the following :- Plaque index system (PLI) Gingival index (GI), Probing pocket depth (PPD) and Bleeding on probing (BoP) Results : The study based on three periodontal parameters to asses the results of study, first of which is plaque index and there was a significant low in all groups from the base line until the 4th visit while the bleeding on probing showed a highly significant difference between the groups whom take antibiotics as an adjunctive to a non surgical treatment and the group without antibiotics.

While for probing pocket depth the difference was only between the groups whom take Azithromycin and control group this difference was start in the 2nd visit until the last visit Conclusion : Although both treatment strategies seemed to be a successful therapy, the adjunctive use of 500 mg azithromycin systemically enhanced the clinical results.