بعض التغييرات الفسلجية بفعل مركب Metronidazole المستخدم لعلاج Giardia lamblia لدى الإنسان

Abstract EN

The study aimed to introduce the effect of Giardia lamblia infection on changes in some biochemical parameters in serum of infected patients before and after treatment during a period of one year, (from Feb, 2008 to Jan, 2009).

Samples of 50 infected patients who referred to Al-Kadimiyah Teaching Hospital, were collected before and after 7 days of treatment.

The activity of liver enzymes (Gpt and Got) before treatment increased significantly as it reached up to (8.47) u/L and 19.06 u/L, comparing with control values (6.455) u/L and (8.39) u/L respectively.

The activity of the enzymes decreased after treatment but the values of Gpt and Got remained higher than the control values as reached 7-27 u/L, 11-64 u/L.

The concentration of creatinine before treatment significantly increased slightly (p<0.005) and reached (0.75) mg/dl then it decreased after treatment and reached 0.73 mg/dl comparing with control 0.618 mg/dl.

Also, slight increase in the concentration of Na+ before treatment as it reached 144.4 mmol/L then decreased after treatment and reached 136.3 mmol/L comparing with control 138.2 mmol/L high significant increase (p<0.005) in the concentration of K+ before treatment as it reached 5.02 mmol/Lit decreased after treatment and reached 4.03 mmol/L comparing with control values 3.86 mmol/L significant decrease (p<0.01) in the concentration of Iron before treatment as it reached 13.73 mmol/L comparing with control values 23.0 mmol/L then it increased after treatment and reached 15.06 mmol/L.

Significant decrease (p<0.01)in the levels of vitamins (E, C and A) in all patients serum before treatment as it reached 0.219 mg/dl, 1.28 mg/dl, 0.58 mg/dl comparing with control values 0.332 mg/dl, 1.39 mg/dl, 1.06 mg/dl then it increased after treatment and reached 0.328 mg/dl, 1.434 mg/dl, 1.11 mg/dl.