The relationship of heat shock protein-70 (HSP-70) and toxoplasmosis among women with abortion
Joint Authors
Sultan, Baqur A.
al-Jabburi, Salman Aziz Adus
al-Saghir, Hana A.
Muhammad, Karim Ghali
Source
Kufa Journal for Nursing Sciences
Issue
Vol. 2, Issue 1 (30 Apr. 2012)8 p.
Publisher
University of Kufa Faculty of Nursing \
Publication Date
2012-04-30
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Topics
Abstract AR
مرض داء المقوسات من الأمراض الواسعة الانتشار في مجتمعاتنا،علاوة على كونه یلعب دورا مھما في إحداث الإسقاط لدى النساء الحوامل.
أجريت ھذه الدراسة لمعرفة دور Heat Shock Protein-70 (HSP-70) في الاستجابة المناعية ضد ھذا المرض لدى النساء اللاتي عانین إسقاطا.
تضمنت تلك الدراسة جمع عینات من دم (٣٥) من أولئك المرضى و الذي ثبت مختبریا إصابتھن بھذا المرض كما تم جمع عینات من (20) من النساء الأصحاء كمجموعة ضابطة، تراوحت أعمار من شملتھم تلك الدراسة مابین 15-50 سنة و للفتره مابین مایس 2010 و مايس 2011 و قد تم قياس مستوى HSP-70 في مصل أولئك المرضى و المجموعة الضابطة بالإضافة إلى قیاس السایتوكاین العاشر (10-Interleukin)، السایتكاین الثاني عشر (IL-12) و الكاما انتفیرون (Gamma Interfeon, IFNγ) و أخيرا تم قیاسھن بعد اخذ العلاج اللازم.
أظهرت نتائج تلك الدراسة زيادة و بصوره معنویة في مستوى ال (HSP-70) في دم أولئك المرضى (pg / ml 4.138) في المراحل المبكرة من الإصابة عند مقارنتھا لمستواه في المجموعة الضابطة و مجموعة المرضى بعد اخذھم العلاج اللازم (pg / ml, 1.01 pg / ml 1.990) و على التوالي، كما تبین بان الزيادة في مستوى HSP-70 ترافق مع الزيادة الحاصلة في مستوى (IFNγ & IL-12) في المراحل المبكرة للمرض (pg / ml 81.2 ; pg / ml 19.023) و على التوالي.
Abstract EN
Toxoplasmosis is a wide spread disease in our society, moreover it plays an important role in causation of abortion in pregnant women.
The present study was carried out to evaluate the role of Heat Shock Protein-70 (HSP-70) in the immune response against infection with Toxoplasma gondii among women with abortion.
The present study was carried out on (35) women, all of them having abortion and proved by confirmatory tests that they have an active form of toxoplasma infection.
It also included twenty apparently healthy women as a control group.
The patients were between 15 to 50 years of age, blood samples were collected from them during the period between May 2010 to May 2011.
The Cytokines that were measured among studied groups by ELISA technique included HSP-70, Interleukin-10 (IL10) Gamma Interferon (IFNγ) and Interleukin-12 (IL-12), thereafter cytokines were remeasured after, receiving complete course of treatment.
The study showed a high significant increase in serum level of HSP-70 in patients with IgM seropositivity (4.138pg / ml) when compared with serum levels in control and post treated groups (1.990 pg / ml, 1.015pg / ml) respectively.
It was also found that there was a concomitant increase in serum level of HSP-70 and serum level of both IFNγ and IL-12 in the early stage of acute infection (19.023, 81.292) Respectively.
American Psychological Association (APA)
Muhammad, Karim Ghali& Sultan, Baqur A.& al-Jabburi, Salman Aziz Adus& al-Saghir, Hana A.. 2012. The relationship of heat shock protein-70 (HSP-70) and toxoplasmosis among women with abortion. Kufa Journal for Nursing Sciences،Vol. 2, no. 1.
https://search.emarefa.net/detail/BIM-315768
Modern Language Association (MLA)
Muhammad, Karim Ghali…[et al.]. The relationship of heat shock protein-70 (HSP-70) and toxoplasmosis among women with abortion. Kufa Journal for Nursing Sciences Vol. 2, no. 1 (2012).
https://search.emarefa.net/detail/BIM-315768
American Medical Association (AMA)
Muhammad, Karim Ghali& Sultan, Baqur A.& al-Jabburi, Salman Aziz Adus& al-Saghir, Hana A.. The relationship of heat shock protein-70 (HSP-70) and toxoplasmosis among women with abortion. Kufa Journal for Nursing Sciences. 2012. Vol. 2, no. 1.
https://search.emarefa.net/detail/BIM-315768
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references.
Record ID
BIM-315768