Type 2 diabetic nephropathy in uncontrolled patients treated with daonil and glucophage

Abstract EN

Type 2 diabetes mellitus is similar to type 1 and other forms of diabetes in that it is defined by high levels of plasma glucose and is associated with many long-term complications caused or enhanced by hyperglycemia and related metabolic abnormalities.

Levels of glucose, glycohemoglobin (HbA1c), insulin, insulin resistance, creatinine, urea, eGFR, microalbominurea, β2-microglobulin concentraions in sera ,blood, and urine of 298 patients diabetes mellitus treated with daonil(149), glucophage (149) and 83 apparently healthy who served as control.

The results showed a highly significant increase p < 0.001 in glucose, HbA1c, insulin, insulin resistance, albumin, creatinine, microalbominurea, concentrations in patient with diabetes mellitus treatment with daonil and glucophage (less and more than 5y) when compared to control group.

Also a highly significant increase p < 0.001 of urea, eGFR, β2-microglobulin concentrations(more than 5y).β2-microglobulin concentrations a significant increase p < 0.05 in the urine (≤ 5y).