Polycondensation of allopurinol with EDTA and CDTA as chelation polymers for transition metals

Abstract EN

a known drug for the treatment of gout and hyperuricaemia, with ethylendiaminetetraacetic acid (EDTA) or cyclohexyldiaminetetraacetic acid (CDTA).

The prepared condensed polymers were characterized by using the following spectrometric techniques: UV-visible, 1H-NMR and FT-IR.

Their thermal behavior were studied by using thermogravimetric analysis, The intrinsic viscosities in DMF were calculated, and their % swelling in water was measured at 30°C.Their softening point were measured, Also the carboxylic acid functional groups content were measured by acid-base titration.

When they were polymerized with as a diamine drug compound; these new drug polymers were modified with metal ions as good ligand, which could be complexes with many poison metal ions.