Physiological study of chronic renal failure according to peripheral neuropathy

Abstract EN

Bachground: Chronic renal failure (CRF) is a pathological syndrome developed due to a progressive destruction of renal structures by chronic nephropathies.

It is characterized by gradually increasing renal functions impairment.

peripheral neuropathy is one of the most common neurological complications of CRF , the mechanism of production of neuropathy is that accumulation of slowly dialyzable middle molecules (500- 2000 Daltons) which may include methylguanidine, parathyroid hormones, β2 microglobulin and myoinositol, can be correlated with the degree of neurotoxicity.

Objective: This study aims to estimate the variations in the peripheral nerve via electrophysiological changes in patients suffering from CRF on continuous hemodialysis with uremic peripheral neuropathy and without uremic peripheral neuropathy since the changes in these parameters are important in detecting, quantifying, identifying some possible risk factors and assessing patient’s response to treatment.

Method: The study lasted from November/2010 to April /2011 in Marjan Teaching Hospital..

The study was carried out on 100 persons ( 70 patients and 30 healthy persons as a control group) .

The patients and controls were classified into four age groups.

Also the patients suffering from CRF on continuous hemodialysis classified into patients with uremic peripheral neuropathy and without uremic peripheral neuropathy .

The patients and controls enrolled in the study had undergone full assessment that included:- electrophysiological assessment for the following nerves ( median ,ulnar ,peroneal ,tibial and sural nerve ) that involved the sensory and motor nerve conduction studies.

Results: Regarding electrophysiological changes patients had shown significant increase in latency for sensory and motor nerves and significant decrease in amplitude and conduction velocity for sensory and motor nerves in patients with peripheral neuropathy than that of the controls and patients without peripheral neuropathy .

Conclusion: The results of this study supports the hypothesis that CRF is a critical disease that results in a multi-systemic disorders The incidence of uremic peripheral neuropathy present to be very high in this study .

Therefore, a good attention should be directed to study this problem and seriously creates the suitable solutions.