Spectrophotometric determination of metformin hydrochloride via oxidative coupling reaction with 1-naphthol in pharmaceutical and environmental water sample
Joint Authors
Ahmad, Nayif Rahman
Umar, Farah Khalaf
Source
Iraqi National Journal of Chemistry
Issue
Vol. 2012, Issue 46 (30 Jun. 2012), pp.161-170, 10 p.
Publisher
University of Babylon College of Sciences
Publication Date
2012-06-30
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Topics
Abstract AR
تم وصف طريقة طيفية سهلة و سريعة و حساسة لتقدير المتفورمين هيدروكلورايد.
تعتمد الطريقة على أكسدة 1–نافثول بواسطة هايبوكلورات الصوديوم و اقترانه مع المتفورمين هيدروكلورايد بوجود هيدروكسيد الصوديوم لتكوين ناتج أزرق اللون ذائب في الماء و له أقصى امتصاص عند 580 نانو متر.
لقد وجد بأن قانون بير يسري على الكميات التي تتراوح بين 20-2 مايكروغرام / مل بامتصاصية مولارية مقدارها 104 × 3.66 لتر / مول.سم.
تعد الطريقة الحالية بسيطة كونها لا تحتاج إلى تسخين أو تحلل مائي أو استخلاص مذيبي حيث أن المواد الداخلة في تحضير المستحضرات المحللة لا تتداخل مع المتفورمين هيدروكلورايد مما جعلها طريقة ناجحة للتحليل الروتيني للمتفورمين هيدركلورايد بشكله النقي و في مستحضراته الصيدلانية (الحبوب) و في نموذج بيئي من المياه.
Abstract EN
A simple, rapid, accurate and sensitive spectrophotometric method for determination of metformin hydrochloride has been developed.
The proposed method is based on the oxidation of 1-naphthol by sodium hypochlorite and coupling with metformin hydrochloride in the presence of sodium hydroxide to form an intense blue soluble product with maximum absorption at 580 nm.
Beerˈs law is obeyed over the concentration range of 2-20μg/ml, with molar absorptivity of 3.66x104 l/mol.cm.The present method is considered to be simple because it does not need either heating or hydrolysis or solvent extraction steps.
The ingredients often formulated with metformin hydrochloride have been shown not to interfere, and the proposed method is suitable for the routine determination of metformin hydrochloride.
The method has been successfully applied for the determination of metformin hydrochloride in pure form, pharmaceutical preparations(Tablets) and environmental water sample
American Psychological Association (APA)
Ahmad, Nayif Rahman& Umar, Farah Khalaf. 2012. Spectrophotometric determination of metformin hydrochloride via oxidative coupling reaction with 1-naphthol in pharmaceutical and environmental water sample. Iraqi National Journal of Chemistry،Vol. 2012, no. 46, pp.161-170.
https://search.emarefa.net/detail/BIM-316288
Modern Language Association (MLA)
Ahmad, Nayif Rahman& Umar, Farah Khalaf. Spectrophotometric determination of metformin hydrochloride via oxidative coupling reaction with 1-naphthol in pharmaceutical and environmental water sample. Iraqi National Journal of Chemistry No. 46 (Jun. 2012), pp.161-170.
https://search.emarefa.net/detail/BIM-316288
American Medical Association (AMA)
Ahmad, Nayif Rahman& Umar, Farah Khalaf. Spectrophotometric determination of metformin hydrochloride via oxidative coupling reaction with 1-naphthol in pharmaceutical and environmental water sample. Iraqi National Journal of Chemistry. 2012. Vol. 2012, no. 46, pp.161-170.
https://search.emarefa.net/detail/BIM-316288
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 169-170
Record ID
BIM-316288