Study of some biochemical changes in serum of patients with chronic renal failure

Abstract EN

The present study is concerned with the investigation of the activity of the folling enzymes adenosine deaminase (ADA), `5-nucleatidase (`5-NT) and amylase.

The concentration of selenium (Se), iron (Fe), sodium (Na), potassium (K), peroxynitrite and vitamin A have been measured in blood serum from patients with chronic renal failure (CRF) undergoing hemodialysis .

Thirty-five patients with CRF before and after having hemodialysis and 62 healthy controls were included in this study.

The results showed a significant decreased in serum ADA activity of CRF patients while `5-NT and amylase activities were significantly increase in these patients when compared with blood serum from normal individuals.

The concentration of Se, Fe, Na and vitamin A were significantly decreased while peroxynitrite was significantly increased.

Potassium was increased, but the increase was statistically insignificant.

In a comparative study in pre-and post hemodialysis cases, serum `5-NT activity and Na concentration in post hemodialysis patients were significantly decreased but the ADA activity and Fe concentration were significantly increased than those in the pre hemodialysis patients.

There was no significantly difference in the serum activity of amylase and in the concentration of Se, K, peroxynitrate and vitamin A.

In conclusion, hemodialysis patients exhibit some biochemical changes before and after the dialysis when compared with control group.