Pharmacokinetics and bioavailability of spectinomycin in sheep

Abstract EN

Spectinomycin is one of aminocyclitol antibiotics used in Veterinary Medicine.

It is used for treatment of bacterial respiratory and enteric infections.

The pharmacokinetics and bioavailability of spectinomycin were conducted in healthy sheep after administration of a single dose (20 mg kg-1 bw.) intravenous (i.

v.) and intramuscular (i.

m.) was studied.

The microbiological assay method was used.

Serum concentration time curve was best described as two compartment open model.

The distribution and elimination half lives (t 0.5 (α), t 0.5 (β)) were 0.175 ± 0.048 h and 2.078 ± 0.419 h., respectively.

Spectinomycin distributed extravasculary with a volume of distribution Vd (ss) 0.187 ± 0.029 L kg-1, with total body clearance (CLB) of 0.0786 ± 0.006 L kg-1h-1.

Following intramuscular injection, spectinomycin was absorbed with t 0.5(ab ) 0.124 ± 0.063 h and eliminated with t 0.5 (el) 3.995 ± 0.082 h.

The peak serum concentration was 32.478 ± 1.19 μg ml-1 attained at Tmax of 0.667 ± 0.023 h.

The systemic bioavailability (F) of spectinomycin after i.

m.

injection was 80.51 % and the serum protein binding tendency was 2.814%.