Isosorbide mononitrate versus misoprostol for cervical ripening

Abstract EN

Back ground : chronic total occlusion (CTO) of coronary arteries remains one of the most challenging lesion subsets in interventional cardiology even with the development of medical devices and operator expertise.

Successful revascularization results in improved in angina status, increased exercise capacity and reduces the need for lat.

CABG surgery.

Objectives : this study sought to determine the overall procedural success rate of percutaneous coronary intervention (PCI) for CTOs and to examine the relation between variables such as ; patients’ characteristics, risk factors, lesion characteristics and procedural success rate.

Methods : in this study ,clinical and coronary angiography data of (80) patients with CTO who underwent PCI between May 2009 and May 2010 in Ibn Al-Baitar Hospital for cardiac surgery and Al-Nassryia cardiac center were prospectively analyzed.

The clinical data were collected using the patient's files and angiographic data by review of their films.

Results : there were (80) Patients with CTO, They included 62 men (77.5 %) and 18 women (22.5 %), Age range 36-76 year with mean age 55 ± 8.75 and male to female ratio was 3 : 1.

The procedural success rate of PCI was 66 patients (82.5 %).

All 23patients(100 %) with lesion length less than 15 mm had successful PCI compared to 43 out of 57 patients in whom the lesion was more than 15mm (75.4 %) p value < 0.01.

The procedure was successful in 54 patients out of 60 with tapered stump (90 %) compared to 12 out of 20 patients with abrupt stump (60 %) p value < 0.005.

In CTO lesion with angulations less than 45 degree, the procedure was successful in 27 patients out of 28 (96.4 %) compared to 39 out of 52 patients in whom the angulations was more than 45 degree 52(75 %) p value < 0.01.

The most common cause of procedural UN success was inability of guide wire crossing through the totally occluded segments which represented 11(78.5 %), Inability to cross the lesion with a balloon in 2 patients (14.2 %) and inability to dilate balloon in one patient (7.1 %) P < 0.001.

Conclusion : percutaneous coronary intervention of chronic total occlusion is an effective therapeutic procedure with high success rate 82.5 %.

The length of chronic total occlusion, degree of angulations and stump morphology are strong predictors of success procedure.