Evaluation of superoxide dismutase and malondialdehyde in asthmatic patients in Al-Hilla province

Abstract EN

The present study was conducted to explore the oxidative stress levels in asthma.

To achieve this aim, 87 asthmatic patients, and 46 healthy individuals were enrolled in this study.

The samples were obtained from Babylon Asthma and Allergy center in Hilla city.

The laboratory work was carried out in the research-lab of the departments of biochemistry, college of medicine, Kufa University, Iraq.

Superoxide dismutase activity and malondialdehyde concentrations were determined spectrophotometrically.

The used statistical analysis (student`s t-test) showed a highly significant (p < 0.001) decrease in superoxide dismutase and a highlysignificant (p < 0.001) increase in malondialdehyde concentrations in asthmatic patients when compared with healthy individuals.

The linear regression analysis demonstrated a significant negative correlation for superoxide dismutase (r = -0.63, p < 0.01), and a significant (r = 0.53, p < 0.01) positive correlation for malondialdehyde concentration with age of asthmatic patients.

The statistical analysis indicated a significant negative correlation for superoxide dismutase (r = -0.63, p<0.01) and a significant (r = 0.44, p < 0.01) positive correlation for malondialdehyde concentration with the duration of asthma.

Patients from rural areas showed a significant (p < 0.01) decrease of superoxide dismutase and a significant (p < 0.01) increase of malondialdehyde concentrations when compared to those of urban residency.

The results indicated that asthma is highly associated with oxidative stress.

It may evoke the addition of antioxidant to the treatment of asthma, And those who live in rural area should ingest a high amount of anti-oxidant to ensure the balance between the oxidant species and the well-done anti-oxidant in the cell.