The association between thyroid hormones and lipid profile in patients with primary hyperthyroidism

Abstract EN

Background : Thyroid hormones are important at cellular level, affecting nearly every type of tissue in the body. Objectives : The present study was carried out to determine whether thyroid hormones affect lipid profile in patients with hyperthyroidism. Materials and Methods : This study was carried out on 22 hyperthyroid patients (11 men and 11 women), with mean age 48.5±13.1 years and 24 apparently healthy control (12 men and 12 wome), with mean age 49.5 ± 11.4 years).

Serum levels of, thyroid stimulated hormone TSH, thyroxine (T4) and triiodothyronine (T3) were measured by ELISA technique, and total cholesterol (TC), high-density lipo-protein cholesterol (HDL-C), and Triglyceride (TG) were measured spectrophotometrically, while low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C ) were calculated. Results : Thyroid stimulated hormone TSH, lipids and lipoproteins (TC, TG, HDL-C, LDL-C, VLDL-C ) levels of patients were significantly lower than those of the control group (p > 0.05).

And there were significant increases in serum thyroid hormones T4, T3 values (p > 0.05). Conclusion : Hyperthyroidism is associated with decrease levels of lipoprotein, caused by increased hepatic uptake due to an enhanced affinity for the LDL receptor, and regulatory protein of TG (ApoAV).