Treatment outcome and prognostic factors of adult glioblastoma multiforme
Joint Authors
Ahmadloo, Niloofar
Kani, Amir Abbas
Mohammadianpanah, Muhammad
Nasr Allah, Hamid
Musalai, Ahmad
Ansari, Mansur
Omidvari, Shapour
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 25, Issue 1 (31 Mar. 2013), pp.21-30, 10 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2013-03-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Introduction : This study aimed to report the characteristics, prognostic factors and treatment outcome of 223 patients with glioblastoma multiforme (GBM).
Subjects and method : This retrospective study was carried out by reviewing the medical records of 223 adult patients diagnosed at a tertiary academic hospital between 1990 and 2008.
Patients’ follow up ranged from 1 to 69 months (median 11 months).
Surgery was attempted in all patients in whom complete resection in 15 patients (7 %), subtotal resection in 77 patients (34 %), partial resection in 73 patients (33 %) and biopsy alone in 58 patients (26 %) were done.
In addition, we performed a literature review of PubMed to find out and analyze major related series.
In all, we collected and analyzed the data of 33 major series including more than 11,000 patients with GBM.
Results: There were 141 men and 82 women.
The median progression free- and overall survival were 6 (95 % CI = 5.711–8.289) and 11 (95 % CI = 9.304–12.696) months respectively.
In univariate analysis for overall survival, age (P = 0.003), tumor size (P < 0.013), performance status (P < 0.001), the extent of surgical resection (P = 0.009), dose of radiation (P < 0.001), and adjuvant chemotherapy (P < 0.001) were prognostic factors.
However, in multivariate analysis, only radiation dose, extent of surgical resection, and adjuvant chemotherapy were independent prognostic factors for overall survival.
Conclusion : The prognosis of adult patients with GBM remains poor ; however, complete surgical resection and adjuvant treatments improve progression-free and overall survival.
American Psychological Association (APA)
Ahmadloo, Niloofar& Kani, Amir Abbas& Mohammadianpanah, Muhammad& Nasr Allah, Hamid& Omidvari, Shapour& Musalai, Ahmad…[et al.]. 2013. Treatment outcome and prognostic factors of adult glioblastoma multiforme. Journal of the Egyptian National Cancer Institute،Vol. 25, no. 1, pp.21-30.
https://search.emarefa.net/detail/BIM-319887
Modern Language Association (MLA)
Ahmadloo, Niloofar…[et al.]. Treatment outcome and prognostic factors of adult glioblastoma multiforme. Journal of the Egyptian National Cancer Institute Vol. 25, no. 1 (2013), pp.21-30.
https://search.emarefa.net/detail/BIM-319887
American Medical Association (AMA)
Ahmadloo, Niloofar& Kani, Amir Abbas& Mohammadianpanah, Muhammad& Nasr Allah, Hamid& Omidvari, Shapour& Musalai, Ahmad…[et al.]. Treatment outcome and prognostic factors of adult glioblastoma multiforme. Journal of the Egyptian National Cancer Institute. 2013. Vol. 25, no. 1, pp.21-30.
https://search.emarefa.net/detail/BIM-319887
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 28-30
Record ID
BIM-319887