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Comparing a combination of penicillin G and gentamicin to a combination of clindamycin and amikacin as prophylactic antibiotic regimens in prevention of clean contaminated wound infections in cancer surgery
Joint Authors
al-Mahallawy, Haydar A.
Hassan, Safa Shawqi
Khalifah, Hassan Ibrahim
Safa, Muhammad M. al-Sayyid
Khafaji, Midhat Muhammad
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 25, Issue 1 (31 Mar. 2013), pp.31-35, 5 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2013-03-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background and aim : Appropriate antibiotic selection and timing of administration for prophylaxis are crucial to reduce the likelihood of surgical site infection (SSI) after a clean contaminated cancer surgery.
Our aim is to compare the use of two prophylactic antibiotic (PA) regimens as regards efficacy, timing, and cost.
Patients and methods: Two hundred patients with gastric, bladder, or colorectal cancer were randomized to receive preoperative PA, group a received penicillin G sodium and gentamicin and group B received clindamycin and amikacin intravenously.
The demographic data of patients were collected, and they were observed for wound infections.
Results : Infected wounds occurred in 19 patients with a rate of 9.5 %.
Highest incidence of SSI was among bladder cancer patients (14.2 %) ; p = 0.044.
The rate of SSI was 11 % in group A, and 8 % in group B, p = 0.469.
The cost of PA administered in group A was significantly less than that of group B (21.96 ± 3.22 LE versus 117.05 ± 12.74 LE, respectively ; p < 0.001).
SSI tended to be higher among those who had longer time for antibiotic and incision (P30 min) than those who had shorter time interval (< 30 min), (13 % vs.
6.5 %, respectively).
Conclusion : Both penicillin +gentamicin and clindamycin + amikacin are safe and effective for the prevention of SSI in clean contaminated operative procedures.
In a resource limited hospital, a regimen including penicillin +gentamicin is a cost-effective alternative for the more expensive and broader coverage of clindamycin + amikacin.
Timing of PA is effective in preventing SSIs when administered 30 min before the start of surgery.
American Psychological Association (APA)
al-Mahallawy, Haydar A.& Hassan, Safa Shawqi& Khalifah, Hassan Ibrahim& Safa, Muhammad M. al-Sayyid& Khafaji, Midhat Muhammad. 2013. Comparing a combination of penicillin G and gentamicin to a combination of clindamycin and amikacin as prophylactic antibiotic regimens in prevention of clean contaminated wound infections in cancer surgery. Journal of the Egyptian National Cancer Institute،Vol. 25, no. 1, pp.31-35.
https://search.emarefa.net/detail/BIM-319889
Modern Language Association (MLA)
al-Mahallawy, Haydar A.…[et al.]. Comparing a combination of penicillin G and gentamicin to a combination of clindamycin and amikacin as prophylactic antibiotic regimens in prevention of clean contaminated wound infections in cancer surgery. Journal of the Egyptian National Cancer Institute Vol. 25, no. 1 (2013), pp.31-35.
https://search.emarefa.net/detail/BIM-319889
American Medical Association (AMA)
al-Mahallawy, Haydar A.& Hassan, Safa Shawqi& Khalifah, Hassan Ibrahim& Safa, Muhammad M. al-Sayyid& Khafaji, Midhat Muhammad. Comparing a combination of penicillin G and gentamicin to a combination of clindamycin and amikacin as prophylactic antibiotic regimens in prevention of clean contaminated wound infections in cancer surgery. Journal of the Egyptian National Cancer Institute. 2013. Vol. 25, no. 1, pp.31-35.
https://search.emarefa.net/detail/BIM-319889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 35
Record ID
BIM-319889