Body mass index and pregnancy outcome after assisted reproduction treatment : effect modification of age, infertility type and number of transferred embryo

Abstract EN

Background: The effect of body mass index (BMI) on pregnancy outcome after intra cytoplasmic sperm injection (ICSI) is still controversial.

Objectives: To evaluate the impact of BMI on pregnancy outcome after ICSI and to investigate the modification effect of other factors as age, hormonal profile ect.

Methodology : the study analyzed pregnancy outcome of 349 women underwent ICSI according to their BMI : < 25 kg / m2 (normal), 25- < 30 kg / m2 (overweight) and ≥ 30 kg / m2 (obese).

The associations were generated by applying logistic regression models.

Results : A significant reduction in positive pregnancy outcome was observed among overweight and obese women.

The adjusted odds ratio (OR) was 0.50 (95 %) confidence interval (CI) = 0.25-0.99), and 0.45 (95 % CI = 0.20-0.89) for overweight and obese women respectively.

These estimates showed more reduction among women aged < 27 years and ≥33 years and in primary infertile women.

The reducing effect of overweight and obesity on pregnancy outcome, however, was absent among women with more than two ET.

Conclusion : our study contributes to the reports linking overweight and obesity with decreased positive pregnancy outcome after ICSI, and provides suggestion that women’s age, infertility type and number of ET to modify this reducing effect.