Histological and biochemical study on effect of dried fruit extract of S. nigrum on hepatopathy induced by CCL4

Abstract EN

The results of the present study evaluate the efficiency of dried fruits extract on hepatic damage induced by CCL4.

The histopathological changes were less obvious in livers related to rats in (G111) which treated with the extract and then with CCL4 comparative to histological exam of livers related to rats in (G11) treated with only CCL4 and control animals (G1). In this study we assessed some of hepatic enzymes levels such as GOT, GPT, ALP and total bilirubin in blood serum .

All enzymes showed high significant reduce (p < 0.01) in animals treated with the extract compared to that in animals treated with CCL4 alone and with controls . The results also described the histopathological changes including damage ,necrosis of hepatic cells and central vein congestion in addition to bile ducts hyperplasia in rats livers in (G11) compared with animals in ( G1) and ( G111) . The rats treated with CCL4 resulted in enlargement of livers while the animals treated with extract showed livers normal with size similar to that in control group .