Determination of perindopril erbumine in tablets by spectrophotometry
Joint Authors
Rani, Avula Prameela
Nagalakshmi, Chatragadda
Bhawani, Sunkara
Sekaran, Chandra Bala
Source
Issue
Vol. 7, Issue 4 (31 Dec. 2012), pp.413-426, 14 p.
Publisher
Yarmouk University Deanship of Research and Graduate Studies
Publication Date
2012-12-31
Country of Publication
Jordan
No. of Pages
14
Main Subjects
Topics
Abstract EN
Perindopril erbumine (PDE), used in the treatment of patients with heart failure, belongs to a class of drugs known as angiotensin-converting-enzyme inhibitors.
Four (M1-M4) sensitive, accurate, precise and cost-effective spectrophotometric methods for the determination of PDE in bulk and in tablets dosage forms have been developed and validated.
Method M1 and M2 are based on the formation of chloroform soluble ion-pair complexes of PDE with safranin O and bromothymol blue in basic and acidic medium, respectively.
Method M3 is based on the oxidation of the PDE with alkaline potassium permanganate.
Method M4 involves the ternary complex formation of the PDE with molybdenum (V) thiocyanate.
The colored species showed absorbance maxima at 520, 410, 605 and 750 nm for methods M1, M2, M3 and M4, respectively.
The optimum conditions for all the four methods are optimized.
Beer’s law is obeyed over the ranges 5–25 μg ml-1 (M1) and 2-20 μg ml-1 (M2, M3 and M4).
The apparent molar absorptivity, Sandell’s sensitivity, limit of detection and limit quantification values are reported.
All the methods were validated in accordance with ICH guidelines.
The developed methods were employed with high degree of precision and accuracy for the estimation of drug content in commercial tablets of PDE.
American Psychological Association (APA)
Rani, Avula Prameela& Nagalakshmi, Chatragadda& Bhawani, Sunkara& Sekaran, Chandra Bala. 2012. Determination of perindopril erbumine in tablets by spectrophotometry. Jordan Journal of Chemistry،Vol. 7, no. 4, pp.413-426.
https://search.emarefa.net/detail/BIM-320739
Modern Language Association (MLA)
Rani, Avula Prameela…[et al.]. Determination of perindopril erbumine in tablets by spectrophotometry. Jordan Journal of Chemistry Vol. 7, no. 4 (Dec. 2012), pp.413-426.
https://search.emarefa.net/detail/BIM-320739
American Medical Association (AMA)
Rani, Avula Prameela& Nagalakshmi, Chatragadda& Bhawani, Sunkara& Sekaran, Chandra Bala. Determination of perindopril erbumine in tablets by spectrophotometry. Jordan Journal of Chemistry. 2012. Vol. 7, no. 4, pp.413-426.
https://search.emarefa.net/detail/BIM-320739
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 426
Record ID
BIM-320739