Chlamydia pneumonic infection in coronary heart disease in Basrah

Abstract EN

Aim : the aim of the present study was to determine the relationship between Chlamydia pneumoniae infection and coronary artery disease with classical risk factors in Basrah patients.

Background : chronic inflammatory diseases might play significant role in the pathogenesis of atherosclerosis.

We studied the differences between the percentage of immunoglobulin G against Chlamydia pneumonia among Coronary Heart Disease patients and control subject.

Method : antibody titer against Chlamydia pneumonia by microimmunofluorescence method and C-reactive protein by agglutination method was determined among 225 patients proven Coronary Heart Disease and 180 control subject.

Lipid risk and non-lipid risk factors in Coronary Heart Diseases patients was determined.

Results : chlamydia pneumoniae seropositivity 1 / 64 titer was significantly higher in patients than control group (4.6 % versus 25.5 %) respectively ; P < 0.01 ; odd ratio 2.64 ; CI (1.62 ; 3.46).

Positive C-reactive protein (≥ 6mg / I) was significantly higher in patients (53.3 versus 39.4 ; P< 0.001 ; odd ratio 2.21 ; CI (1.46- 3.11)), than control group.

All percentages of lipid and non-lipid risk factors in patients were significantly higher than control group.

Conclusion : we have demonstrated a significant rise in Chlamydia pneumoniae-specific immunoglobulin G and C-reactive protein levels is associated with Coronary Heart Disease.