Effect of thiopentone sodium on some physiological and anaesthetic parameters in donkeys

Abstract EN

In this study, we studied some pharmacological aspects of thiopentone so-dium in donkeys’ as injectable anaesthetic, and provided baseline data per-taining to side or adverse effects following the use of thiopentone sodium. This study was conducted using 12 clinically healthy male donkeys, 4-10 years of age, weighing 80-150 kg.

They were divided into two groups (6 animals each), and treated with two different doses of Thiopentone sodium i.

e.

10 and 15mg / kg body weight. The respiratory rate, heart rate and rectal temperature were monitored be-fore and at several time points after injection of thiopentone using standard methods ; also blood samples were collected to measure some biochemical parameters (total serum protein, albumin, urea, serum glucose, serum phosphorus, AST and ALT).

The different anaesthetic phases (induction time, anaesthetic, sternal recumbency, lateral recumbency, basal narcosis and recovery time) were measured after injection of thiopentone sodium. Increasing the dose of thiopentone sodium from 10 mg / kg to 15mg / kg re-sulted in significant decrease in induction time (P < 0.05) and significant in-crease in the duration of sternal recumbency and recovery phase.

It was al-so accompanied by prominent, although non- significant (P > 0.05) increase in the duration of anaesthetic phase.

The usage of thiopentone sodium in both protocols tested was accompanied by significant increase (P < 0.05) in heart rate, while rectal temperature expressed non- significant fluctuation. Animals treated with both protocols showed significant decrease (P < 0.05) in respiratory rate immediately following induction of anaesthesia. Animals injected with thiopentone sodium in a dose rate of 10 mg / kg body weight exhibited significant (P < 0.05) increase in the concentration of se-rum glucose, serum urea, and ALT level.

Animals injected with thiopen-tone sodium in a dose rate of 15 mg / kg body weight resulted in non- significant (P > 0.05) changes in all biochemical parameters tested