Evaluation of using two anticollagenolytics (acetylcysteine 3% & autologus blood serum)‎ in treatment of corneal ulcer in dogs

Abstract EN

Fifteen apparently healthy adult male dogs were used in this experiment.

They were assigned into three groups each one contained five dogs (control group, acetylcysteine treatment group and autologus serum treatment group).

The first group was subjected to induction of corneal ulcer without further treatment.

The second group was subjected to treatment of induced corneal ulcer using acetylcysteine solution 3 % as an eye drops three times daily / two months.

The third group was subjected to treatment of induced corneal ulcer using autologus serum as an eye drops 6 to 10 times daily / 1month.

Eyes were evaluated clinically and histopathologically after 7th, 14th, 30th, 60th, 120th day post induction.

Our results revealed that the acetylcysteine alone cannot provide satisfactory management of corneal ulcer in dogs and is always accompanied with many complications such as corneal opacity, descemetocele and corneal perforation ; while the autologus serum alone gives better results than does acetylcysteine but is also accompanied with many complications.