Synthesis of new imidazole derivatives via suzuki-coupling

Dissertant

al-Suud, Husam Husayn

Thesis advisor

al-Suud, Yasin Ahmad

Comitee Members

Mubarak, Muhammad S.
Tashtush, Hasan
Irashid, Fawzi

University

Al albayt University

Faculty

Faculty of Sciences

Department

Department of Chemistry

University Country

Jordan

Degree

Master

Degree Date

2011

English Abstract

A new series of 4-nitroimidazole derivatives bearing substituted piperazines (61 a-1) were synthesized via Suzuki-Coupling between 4-(4-bromo-phenyl)-l-(l-Benzyl-2-ethyl-4-nitro-lH-imidazol-5-yl)-piperazine (58) which was used as starting material for the synthesis of our targets molecules, and the appropriate moronic acid.

The prepared compounds were separated, purified, and their structures confirmed by mean of H-NMR, ’3C-NMR, LC-mass spectrometry and elemental analysis (H, c, N).

The in vitro anti-HIV-1 (strain Ilia) anti-HIV-2 (strain ROD) activities of the synthesized compounds in human T-lymphocyte were tested, compound (61 k) displayed ability to inhibit HIV-1 and HIV-2 replication in cell culture.

These results suggest that compound (61 k) should be considered as a new lead in the development of antiviral agents.

The present work describes the synthesis and biological evaluation which led to the identification of new class of imidazoles as HIV inhibitors.

Main Subjects

Chemistry

No. of Pages

92

Table of Contents

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Language

English

Data Type

Arab Theses

Record ID

BIM-321461