Synthesis and characterization of new 1,2,4-triazole-3-carbohydrazide derivatives as anti¬bacterial agents

Dissertant

al-Balushi, Abd Allah Muhammad Murad

Thesis advisor

al-Suud, Yasin Ahmad

Comitee Members

al-Talib, Mahmud
al-Saduni, Haytham H.
Yaqub, Yaqub H.

University

Al albayt University

Faculty

Faculty of Sciences

Department

Department of Chemistry

University Country

Jordan

Degree

Master

Degree Date

2012

English Abstract

A new series of l, 5-dialkyl-l, 2, 4-Triazole derivatives (51a-h), (52b-g), (53i, j), and (54k) were synthesized, eharcrizcd, and biologically evaluated.

Hydrazine derivatives were prepared by reaction of l, dikyl-l, 2, 4-triazole with different sulfonyl chlorides and carbonyl chlorides derivatives.

The prepared compounds were separated, purified, and their structures were confirmed by means of 1H-NMR, 13C-NMR and elemental analysis (H, c, N, S).

The in vitro anti-bacterial activity of selected compounds, namely, (51c), (52d, g, e) were evaluated against the Gram-positive bacterial strains Staphylococcus aurous and Bacillus cereus, as well as the Gram-negative bacterial strains Pseudomonas aeruginosa and Shigella sp.

The antibacterial testing revealed that the compound (51c) was the most active a compound against Pseudomonas aeruginosa compared with Penicillin.

Main Subjects

Chemistry

Topics

• Bacterioses
• Chemotherapy
• Antibacterial agents

No. of Pages

105

Table of Contents

• APA
• MLA
• AMA

Language

English

Data Type

Arab Theses

Record ID

BIM-321471