Evaluation of some biochemical parameters in relation to acute renal failure

Abstract EN

Glomerular filtration rate (GFR) is the best overall index of renal function in health and disease.

Recently, Cystatin C (Cyst C), a low molecular weight protein freely filtered through the glomerulus, and almost completely reabsorbed and catabolized by tubular cells, has been proposed as a new and very sensitive serum marker of change in GFR.

This study investigated the role of Cyst C and other biochemical parameters in the diagnosis of acute renal failure in male rats treated with cisplatin chemotherapy.

The present study was carried out on a total number of 56 adult male Spraque Dawley rats, weighing 150-200g, divided into 2 groups : (1st group served as a control, 2nd group used as acute renal failure model).

Cisplatin induced acute nephrotoxicty that was revealed by increased serum creatinine, urea, BUN and Cystatin C.

It also produced a disturbance in electrolyte through decrease sodium and increase potassium levels.

Cisplatin also produce a disturbance in mineral metabolism through hyper-phosphatemia and hypo-calcemia.

So these finding suggested that serum Cyst C (a cysteine protease inhibitor) has been suggested as a new marker for detection of acute renal failure.