The effect of calendula officinalis in therapy of acetic acid induced ulcerative colitis in dog as an animal model
Joint Authors
Amini, M.
Ashraf, M. J.
Tanidih, N.
Amini, A.
Mihrabani, D.
Ziai, M.
Husayni, S. V.
Ghahramani, L.
Bananzadih, A. M.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 13, Issue 12 (31 Dec. 2011), pp.884-890, 7 p.
Publisher
Publication Date
2011-12-31
Country of Publication
United Arab Emirates
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background : In patients with ulcerative colitis (UC), the repeated cycle of injury and repair of intestinal mucosa has been reported to increase the risk of colon cancer.
So, a safe and efficient therapy is required for the treatment and prophylaxis for the disease.
This study aims to investigate the efficacy of Calendula officinalis extract in treatment of experimentally induced ulcerative colitis in dog animal model.
Methods : During fall 2010, 10 out-bred female German dogs (1-2 years old; weighs of 20-25 kg) were enrolled.
Ulcerative colitis was induced with 6 % acetic acid as enema and method of treatment was retrograde (via enema) too by C.
officinalis.
Results : Loose stools, diarrhea, gross bleeding and loss of body weight happened after administration of acetic acid and crypt damage, loss of epithelium, infiltration of inflammatory cells and depletion of goblet cells were noticed histologically.
C.
officinalis could successfully resolve the damages of UC.
Conclusion : Treatment with C.
officinalis can broaden the current therapy options for UC.
American Psychological Association (APA)
Mihrabani, D.& Ziai, M.& Husayni, S. V.& Ghahramani, L.& Bananzadih, A. M.& Ashraf, M. J.…[et al.]. 2011. The effect of calendula officinalis in therapy of acetic acid induced ulcerative colitis in dog as an animal model. Iranian Red Crescent Medical Journal،Vol. 13, no. 12, pp.884-890.
https://search.emarefa.net/detail/BIM-321710
Modern Language Association (MLA)
Mihrabani, D.…[et al.]. The effect of calendula officinalis in therapy of acetic acid induced ulcerative colitis in dog as an animal model. Iranian Red Crescent Medical Journal Vol. 13, no. 12 (Dec. 2011), pp.884-890.
https://search.emarefa.net/detail/BIM-321710
American Medical Association (AMA)
Mihrabani, D.& Ziai, M.& Husayni, S. V.& Ghahramani, L.& Bananzadih, A. M.& Ashraf, M. J.…[et al.]. The effect of calendula officinalis in therapy of acetic acid induced ulcerative colitis in dog as an animal model. Iranian Red Crescent Medical Journal. 2011. Vol. 13, no. 12, pp.884-890.
https://search.emarefa.net/detail/BIM-321710
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 880-890
Record ID
BIM-321710