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P53 expression in ovarian tumors : an immunohistochemical study
Joint Authors
Hamdi, Iylaf Abd al-Wahhab
Salim, Shuayb H.
Source
Annals of the College of Medicine Mosul
Issue
Vol. 38, Issue 2 (31 Dec. 2012), pp.73-79, 7 p.
Publisher
University of Mosul College of Medicine-Mosul
Publication Date
2012-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
Abstract AR
الأهداف : تم إجراء هذه الدراسة لتقييم حالة الظهور المناعي لبروتين p53 في أورام المبيض في مدينة الموصل و الربط بينها و بين مختلف الصفان المرضية السريرية للورم و مقارنة هذه النتائج مع نتائج لدراسات أخرى. الحالات و الطرق : إن هذه الدراسة مستقبلية و رجعية تم من خلالها جمع 60 حالة من أورام المبيض (49 حالة من سرطان المبيض, 5 حالات من أورام المبيض المتوسطة, بالإضافة إلى 6 حالات من أورام المبيض الحميدة). تم جمع هذه الحالات من مستشفى الجمهوري, السلام العام, الخنساء التعليمي, و بعض المختبرات الخاصة خلال فترة 8 أشهر امتدت من شهر حزيران 2009 إلى شهر كانون الثاني 2010.
لقد تم التحري عن بروتين P53 بطريقة مناعية - نسيجية - كيميائية. النتائج و الاستنتاجات : لقد تراوحت أعمار المرضى بين 13 و 80 سنة.
و تم تقسيم الحالات السرطانية نسيجا إلى 32 حالة لسرطان المبيض السطحي الظهاري و 3 حالات لسرطان الخلايا الجنسية (التناسلية) و 14 حالة للسرطان المتعلق بالسدى و الجنس و 5 حالات من أورام المبيض المتوسطة.
بالإضافة إلى 6 حالات من أورام المبيض الحميدة.
و قد ظهر بروتين p53 في 26 حالة (48.1%) من حالات سرطان المبيض و أورام المبيض المتوسطة.
Abstract EN
Objectives : The aim of this study, first, to evaluate the frequency of immunohistochemical expression of p53 in different types of ovarian tumors, second, to correlate p53 expression with age of patients, histological type and grade of tumors, and third, to compare the results with those of others.
Methods : This study was performed on 60 primary ovarian tumors.
Samples were obtained in a prospective and retrospective fashion (cross sectional study).
The samples were collected from Al-Jumhuri Teaching Hospital, Al-Salaam General Hospital, Al-Khansaa Teaching Hospital, and some private Laboratories, during a period of eight months, from June 2009 through January 2010.
P53 expression was assessed immunohistochemically.
Results : The patients' age ranged from 13 to 80 years, with a mean of 43.88 year.
Most of them were in the fifth decade (28.3 %).
Data concerning the age were missing in five patients.
P53 immunoreactivity was observed in 48.1 % of the malignant tumors.
It was positive in 13 of 20 cases of serous adenocarcinoma, in all of the 5 cases of mucinous adenocarcinoma, in 3 of 12 granulosa cell tumors, in 2 of 4 endometrioid carcinomas, in 1 of 3 clear cell carcinoma, in 1 of 2 dysgerminomas, and in the one case of Sertoli-Leydig cell tumor.
It was negative in malignant thecoma, malignant teratoma and in all borderline and benign tumors.
Statistically p53 expression was not significantly related to the age of the patients, grade, or to the histological type of the tumors.
It was mainly found in malignant serous tumors (50 %), in the poorly differentiated tumors (47.6 %), and in the 6th decade of age (30.8 %).
Conclusions : P53 was expressed in 48.1 % of malignant ovarian tumors, 80.8 % were epithelial tumors, 15.4 % were sex cord-stromal tumors, and 3.8 % were germ cell tumors, and it was negative in benign and borderline tumors.
American Psychological Association (APA)
Hamdi, Iylaf Abd al-Wahhab& Salim, Shuayb H.. 2012. P53 expression in ovarian tumors : an immunohistochemical study. Annals of the College of Medicine Mosul،Vol. 38, no. 2, pp.73-79.
https://search.emarefa.net/detail/BIM-322053
Modern Language Association (MLA)
Hamdi, Iylaf Abd al-Wahhab& Salim, Shuayb H.. P53 expression in ovarian tumors : an immunohistochemical study. Annals of the College of Medicine Mosul Vol. 38, no. 2 (2012), pp.73-79.
https://search.emarefa.net/detail/BIM-322053
American Medical Association (AMA)
Hamdi, Iylaf Abd al-Wahhab& Salim, Shuayb H.. P53 expression in ovarian tumors : an immunohistochemical study. Annals of the College of Medicine Mosul. 2012. Vol. 38, no. 2, pp.73-79.
https://search.emarefa.net/detail/BIM-322053
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 78-79
Record ID
BIM-322053