Cyclization of semicarbazones to 1,2,3-selenadiazoles by selenium dioxide

Abstract EN

In the present work some of 1,2,3-selenadiazole compounds derived from corresponding semicabazones have been prepared.

The reaction of substituted chalcone compounds (1a-c) and 4-methoxy benzyl cyanide give compounds (2a-c) which were converted through the reaction with semicarbazide hydrochloride into the corresponding semicarbazones (3a-d(.

The treatment of these compounds with selenium dioxide leads to ring closure of semicarbazones to give the 1,2,3-selenadiazole compounds.

The structures of the synthesized compounds were established by physical and spectral methods