Design and synthesis of some nitrate derivatives of mefenamic acid with expected nitric oxide release
Other Title(s)
تصميم و تخليق بعض مشتقات النترات لحامض الميفيناميك مع توقع تحرر لأوكسيد النتريك
Joint Authors
Qasir, Ahlam Jamil
Sadun, Ahmad Abd al-Wahid
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 21, Issue 2 (31 Dec. 2012), pp.24-30, 7 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2012-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
Abstract AR
تتضمن الدراسة تصميم و تخليق مركبين جديدين هما عبارة عن مشتقات حامض الميفينامك مع الكلايسين مع نترات عضوية (2– نايتروكسي إيثانول أو 1، 3- داينايتروكسي -2- بروبانول).
العديد من البحوث الحديثة تؤيد الدور المشابه بين أوكسيد النايتريك و البروستوكلاندين في حماية القناة المعوية و معالجة تقرحاتها.
بناءا على ذلك نفترض بأن هذين المشقتقين الجديدين سيساهمان في تقليل الأعراض الجانبية للأدوية غير الستيرويدية المضادة للإلتهاب على القناة المعوية.
Abstract EN
This study include design and synthesis of 2 derivatives of compounds consisting of mefenamic acid, glycine and organic nitrates (2-nitrooxy ethanol or 1, 3-dinitrooxy-2-propanol).
Nitric oxide NO has been reported to support many of the same mucosal protection mechanisms as prostaglandins and is sufficient for acute gastroprotection and ulcer healing.
So we suppose these 2 compounds would reduce non-steroidal anti-inflammatory drugs NSAIDs gastrointestinal side effect.
American Psychological Association (APA)
Sadun, Ahmad Abd al-Wahid& Qasir, Ahlam Jamil. 2012. Design and synthesis of some nitrate derivatives of mefenamic acid with expected nitric oxide release. Iraqi Journal of Pharmaceutical Sciences،Vol. 21, no. 2, pp.24-30.
https://search.emarefa.net/detail/BIM-322858
Modern Language Association (MLA)
Sadun, Ahmad Abd al-Wahid& Qasir, Ahlam Jamil. Design and synthesis of some nitrate derivatives of mefenamic acid with expected nitric oxide release. Iraqi Journal of Pharmaceutical Sciences Vol. 21, no. 2 (2012), pp.24-30.
https://search.emarefa.net/detail/BIM-322858
American Medical Association (AMA)
Sadun, Ahmad Abd al-Wahid& Qasir, Ahlam Jamil. Design and synthesis of some nitrate derivatives of mefenamic acid with expected nitric oxide release. Iraqi Journal of Pharmaceutical Sciences. 2012. Vol. 21, no. 2, pp.24-30.
https://search.emarefa.net/detail/BIM-322858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 29-30
Record ID
BIM-322858
