Detection of homozygous G. IVS5 + 1G > A, G. IVS34-1G > C and C. 886C > T mutations among toxic goiter and thyroid cancer patients in Iraq
Other Title(s)
تعقب الطفرات الوراثية متجانسة الزيجة g. IVS5 + 1G > A, g. IVS34-1G > C, c. 886C > T في مرضى تضخم الغدة الدرقية السام و سرطان الغدة الدرقية في العراق
Joint Authors
al-Faysal, Abd al-Husayn Muwayt
Abd al-Hasan, Ismail Abd al-Rida
al-Ramahi, Intisar Jawad
Source
Iraqi Journal of Biotechnology
Issue
Vol. 11, Issue 2 (31 Dec. 2012), pp.414-421, 8 p.
Publisher
University of Baghdad Genetic Engineering and Biotechnology for Postgraduate Studies
Publication Date
2012-12-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Topics
Abstract AR
حللت 48 عينة DNA تعود إلى 31 مريض بتضخم غدة الدرقية السام و 17 مريض بسرطان الغدة الدرقية من أجل تعقب الطفرات الوراثية لT وجد من خلال التحليل إن هناك ثلاثة طفرات وراثية متجانسة الزيجة. Homozygous إثنان منها تم تعقبها في مريضين بتضخم غدة الدرقية السام و كانت الطفرات عبارة عن استبدال مكافئ للجوانين بالادنين (+A <1G+ g.IVS5) في الموقع 1+ لفاصل المحور 5 و استبدال غيرمكافئ للجوانين بالسايتوسين(( C< g.IVS34 – 1G في المحور 34. أما الطفرة الثالثة متجانسة الزيجة المسجلة فقد تم تعقبها في مريض بسرطان الغدة الدرقية و كانت عبارة عن استبدال مكافئ للسايتوسين بالثايمين في المحور7. ((T
Abstract EN
Forty eight DNA samples from 31 toxic goiter patients and 17 thyroid cancer patients were analyzed to detect g.IVS5+1G>A, g.IVS34-1G>C and c.886C>T mutations of the thyroglobulin (TG) gene.
Among these samples three homozygous mutations were detected.
Two of these mutations were detected in two toxic goiter patients as guanine to adenine transition g.IVS5+1G>A at position +1 of the donor splice acceptor site in exon-intron 5 and transversion that replaced guanine by cysteine (g.IVS34-1G>C) in the exon 34.
The third homozygous mutation was detected among one thyroid cancer patient as transition that replaced cysteine by thymine c.886C>T in the exon 7.
No homozygous g.IVS34-1G>C mutation was detected in thyroid disorders before, to our knowledge this is the first time by which homozygous mutation was detected in one toxic goiter patient.
American Psychological Association (APA)
al-Faysal, Abd al-Husayn Muwayt& al-Ramahi, Intisar Jawad& Abd al-Hasan, Ismail Abd al-Rida. 2012. Detection of homozygous G. IVS5 + 1G > A, G. IVS34-1G > C and C. 886C > T mutations among toxic goiter and thyroid cancer patients in Iraq. Iraqi Journal of Biotechnology،Vol. 11, no. 2, pp.414-421.
https://search.emarefa.net/detail/BIM-322922
Modern Language Association (MLA)
al-Faysal, Abd al-Husayn Muwayt…[et al.]. Detection of homozygous G. IVS5 + 1G > A, G. IVS34-1G > C and C. 886C > T mutations among toxic goiter and thyroid cancer patients in Iraq. Iraqi Journal of Biotechnology Vol. 11, no. 2 (2012), pp.414-421.
https://search.emarefa.net/detail/BIM-322922
American Medical Association (AMA)
al-Faysal, Abd al-Husayn Muwayt& al-Ramahi, Intisar Jawad& Abd al-Hasan, Ismail Abd al-Rida. Detection of homozygous G. IVS5 + 1G > A, G. IVS34-1G > C and C. 886C > T mutations among toxic goiter and thyroid cancer patients in Iraq. Iraqi Journal of Biotechnology. 2012. Vol. 11, no. 2, pp.414-421.
https://search.emarefa.net/detail/BIM-322922
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 420-421
Record ID
BIM-322922
