Treatment results of neo-adjuvant chemotherapy in advanced head and neck cancer in Oman

Joint Authors

al-Khabory, Mazin
Khalifah, Amal

Source

Journal of the Egyptian National Cancer Institute

Issue

Vol. 16, Issue 2 (30 Jun. 2004), pp.99-106, 8 p.

Publisher

Cairo University National Cancer Institute

Publication Date

2004-06-30

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Topics

Abstract EN

Background and Objectives : A prospective, singlearm study was carried out to evaluate the safety and efficacy of neo-adjuvant chemotherapy in advanced head and neck cancer (HNC) in Oman.

Materials and Methods: The study was carried out in the Oncology and Ear, Nose and Throat (ENT) Departments, Muscat, Oman between October 1998 and December 2001.

Eligible, previously untreated patients with confirmed diagnosis of locally advanced non-metastatic carcinoma of the head and neck were examined.

A maximum of three cycles of neo-adjuvant chemotherapy (Cisplatin 100mg / m2 Day 1 plus 5-Fluorouracil 1gm/m2 continuous infusion for four days) were administered, followed by radical radiotherapy according to primary site.

The main end-points were toxicity, response rate, disease-free survival and overall survival.

Results : Seventy-three patients (45 males and 28 females) were eligible; all were evaluable for response and toxicity.

The median age of studied patients was 52 years (range: 17-83 years).

Forty-four patients (60%) had stage III disease and 29 (40%) had stage IV disease.

After neo-adjuvant chemotherapy, Overall Response (OR) [Complete Response (CR) + Partial Response (PR)] was observed in 50 patients (68%), 33 patients (45%) had clinical CR and 17 patients (23%) had PR.

Sixteen patients (22%) showed Stable Disease (SD) and 7 patients (10%) progressed while on chemotherapy.

After completion of radiotherapy, the OR rate was 80%.

Forty patients (55%) had clinically confirmed CR, 18 (25%) had PR, 9 patients (12%) had SD and 6 patients (8%) had progressive disease (PD).

The median follow-up period was 16 months (range 3-48 months).

The initial response to chemotherapy had a significant effect on survival (p= 0.011).

The nasopharyngeal primary was significantly associated with high CR and longer survival (p= 0.01 and 0.02, respectively).

Conclusions : Head and neck carcinoma is not a common malignancy in Oman.

The treatment results with cisplatin and 5-FU compare favorably to similar international studies and treatment-related toxicities are tolerable.

American Psychological Association (APA)

Khalifah, Amal& al-Khabory, Mazin. 2004. Treatment results of neo-adjuvant chemotherapy in advanced head and neck cancer in Oman. Journal of the Egyptian National Cancer Institute،Vol. 16, no. 2, pp.99-106.
https://search.emarefa.net/detail/BIM-32377

Modern Language Association (MLA)

Khalifah, Amal& al-Khabory, Mazin. Treatment results of neo-adjuvant chemotherapy in advanced head and neck cancer in Oman. Journal of the Egyptian National Cancer Institute Vol. 16, no. 2 (Jun. 2004), pp.99-106.
https://search.emarefa.net/detail/BIM-32377

American Medical Association (AMA)

Khalifah, Amal& al-Khabory, Mazin. Treatment results of neo-adjuvant chemotherapy in advanced head and neck cancer in Oman. Journal of the Egyptian National Cancer Institute. 2004. Vol. 16, no. 2, pp.99-106.
https://search.emarefa.net/detail/BIM-32377

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical References: p p 105-106

Record ID

BIM-32377