Immunohistochemical study of some rare vascular tumors
Joint Authors
Ramadan, Muhammad
al-Sayyid, Muna
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 16, Issue 2 (30 Jun. 2004), pp.123-129, 7 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2004-06-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Purpose : Kaposiform-hemangioendothelioma (KHE) is a rare vascular tumor, developing predominantly in infants and children.
Despite its benign histology, this tumor frequently behaves aggressively, causing significant morbidity and mortality.
The striking resemblance of its spindle cell proliferation to that seen in Kaposi sarcoma (KS) led to the designation of KHE for this rare lesion.
This work examined the histopathologic features of KHE and KS and assessed the value of some vascular immunohistochemical markers such as CD34, CD31 and factor VIII associated antigen in routine diagnosis and differential diagnosis of these vascular tumors.
Material and Methods : Three cases of KHE and twenty cases of KS were included in this study.
All specimens are fixed in formalin, embedded in paraffin wax and stained with hematoxylin & eosin and reticulin stains.
The antibodies to CD34, CD31 and factor VIII associated antigen were applied using the streptavidin biotin technique.
Results : Immunohistochemically, all elements within the lesions were labeled with anti-CD34 antibody.
Labeling of spindle cells was less consistent with anti-CD31, while the antibody to factor VIII associated antigen labeled only the well-formed capillaries.
Conclusion : KHE and KS are tumors of endothelial cell origin.
Immuno-staining for CD34, and to a lesser extent, CD31, are more reliable for labeling KHE and KS than the traditional endothelial cell marker, factor VIII associated antigen.
These markers can be used for diagnosis in routinely processed tissue of KS and KHE.
American Psychological Association (APA)
al-Sayyid, Muna& Ramadan, Muhammad. 2004. Immunohistochemical study of some rare vascular tumors. Journal of the Egyptian National Cancer Institute،Vol. 16, no. 2, pp.123-129.
https://search.emarefa.net/detail/BIM-32382
Modern Language Association (MLA)
al-Sayyid, Muna& Ramadan, Muhammad. Immunohistochemical study of some rare vascular tumors. Journal of the Egyptian National Cancer Institute Vol. 16, no. 2 (Jun. 2004), pp.123-129.
https://search.emarefa.net/detail/BIM-32382
American Medical Association (AMA)
al-Sayyid, Muna& Ramadan, Muhammad. Immunohistochemical study of some rare vascular tumors. Journal of the Egyptian National Cancer Institute. 2004. Vol. 16, no. 2, pp.123-129.
https://search.emarefa.net/detail/BIM-32382
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 128-129
Record ID
BIM-32382