Dexmedetomidine vs. Propofol for short-term sedation of postoperative mechanically ventilated patients
Joint Authors
al-Baradi, Samiyah
al-Mahalawy, Fatin H.
Sulayman, Amirah H.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 16, Issue 3 (30 Sep. 2004), pp.153-158, 6 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2004-09-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : Propofol is often used for sedation in the intensive care unit.
The aim of this study was to compare the efficacy and endocrine response of propofol vs.
the new α2-agonist dexmedetomidine for sedation in surgical intensive care patients who need postoperative short-term ventilation..
Methods : Our work is a randomized clinical study conducted on sixty adult patients who required postoperative short term ventilation and sedation.
The patients were allocated randomly, to receive IV infusion of either dexmedetomidine 0.2-0.5 µg / kg / h or propofol 0.5-1 mg / kg / h.
Hemodynamic parameters, Ramsay sedation score, extubation time and serum cortisol and interleukin-6 (IL-6) levels were measured.
Results : Ramsay sedation score was 4.1±1 and 4±0.9 for propofol and dexmedetomidine, respectively, (p=0.59.) Total fentanyl dose in the propofol group was 75±15 µg compared to 15±10.5 µg in the dexmedetomidine group, (p=0.0045).
Patients who received dexmedetomidine infusion had significantly lower heart rates compared to patients who received propofol infusion, (p=0.041).
Preinfusion serum concentrations of IL-6 were comparable in both groups, while the 24h post-infusion levels were insignificantly decreased in both groups compared to preinfusion level, (p=0.36).
There were no intergroup differences in serum cortisol concentrations, (p=0.231.) Conclusion : Dexmedetomidine and propofol are safe sedative drugs for postoperative mechanically ventilated patients.
Patients were easily aroused to co-operate without showing signs of irritations with less fentanyl analgesia in the dexmedetomidine group.
Dexmedetomidine and propofol do not inhibit adrenal function, but they may influence the inflammatory response.
American Psychological Association (APA)
al-Baradi, Samiyah& al-Mahalawy, Fatin H.& Sulayman, Amirah H.. 2004. Dexmedetomidine vs. Propofol for short-term sedation of postoperative mechanically ventilated patients. Journal of the Egyptian National Cancer Institute،Vol. 16, no. 3, pp.153-158.
https://search.emarefa.net/detail/BIM-32410
Modern Language Association (MLA)
al-Baradi, Samiyah…[et al.]. Dexmedetomidine vs. Propofol for short-term sedation of postoperative mechanically ventilated patients. Journal of the Egyptian National Cancer Institute Vol. 16, no. 3 (Jun. 2004), pp.153-158.
https://search.emarefa.net/detail/BIM-32410
American Medical Association (AMA)
al-Baradi, Samiyah& al-Mahalawy, Fatin H.& Sulayman, Amirah H.. Dexmedetomidine vs. Propofol for short-term sedation of postoperative mechanically ventilated patients. Journal of the Egyptian National Cancer Institute. 2004. Vol. 16, no. 3, pp.153-158.
https://search.emarefa.net/detail/BIM-32410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 157-158
Record ID
BIM-32410