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Expression of matrix metalloproteinase-2 in renal cell carcinoma
Joint Authors
Abd al-Wahid, Mushirah M.
Asad, Nansi Yusuf
al-Iskandarani, Muhammad
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 16, Issue 3 (30 Sep. 2004), pp.168-177, 10 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2004-09-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
Abstract EN
Background : Renal cell carcinoma (RCC) is a family of carcinomas arising from the renal tubular epithelium through different genetic lesions.
The most common characteristics of RCC are hyper vascularity, tendency to metastasize widely before giving rise to any symptoms or signs, and poor prognosis.
It has been reported that matrix metalloproteinase (MMPs) are a family of end peptidases implicated in tissue remodeling and cancer invasion.
Therefore, the aim of the present study was to investigate the expression of MMP-2 in RCC and correlate its expression with the clinicopathologic prognostic parameters.
Material and Methods : Fifty cases of primary RCC comprised the material of this study.
Formalin-fixed Paraffin-embedded tissues were stained with MMP-2 immunostaining, using improved streptavidin-biotin amplified system.
The intensity of staining and percentage of positive cells were assessed.
Results : MMP-2 was expressed as diffuse brown cytoplasmic staining in positive cells.
The non-tumorous renal tissue showed negative staining whereas the tumor cells, fibroblasts and vascular endothelial cells showed immunoreactivity in positive cases.
43 / 50 RCC cases studied were positive for MMP-2.
A positive correlation was observed between MMP-2 expression and tumor size, histologic type, capsular & vascular invasion and high levels of cellular proliferation.
Conclusion : It seems that MMP-2 is involved in tumor expansion phenomena associated with tumor progression, invasion of the micro vasculature and distant metastasis of RCC.
American Psychological Association (APA)
Abd al-Wahid, Mushirah M.& Asad, Nansi Yusuf& al-Iskandarani, Muhammad. 2004. Expression of matrix metalloproteinase-2 in renal cell carcinoma. Journal of the Egyptian National Cancer Institute،Vol. 16, no. 3, pp.168-177.
https://search.emarefa.net/detail/BIM-32413
Modern Language Association (MLA)
Abd al-Wahid, Mushirah M.…[et al.]. Expression of matrix metalloproteinase-2 in renal cell carcinoma. Journal of the Egyptian National Cancer Institute Vol. 16, no. 3 (Jun. 2004), pp.168-177.
https://search.emarefa.net/detail/BIM-32413
American Medical Association (AMA)
Abd al-Wahid, Mushirah M.& Asad, Nansi Yusuf& al-Iskandarani, Muhammad. Expression of matrix metalloproteinase-2 in renal cell carcinoma. Journal of the Egyptian National Cancer Institute. 2004. Vol. 16, no. 3, pp.168-177.
https://search.emarefa.net/detail/BIM-32413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 175-177
Record ID
BIM-32413