Immunohistochemical expression of TGF-β in relation to invasion potential evaluated by MMP-2 in oral squamous cell carcinoma
Joint Authors
Sarkis, Sita A.
al-Qazzaz, Haydar H.
Source
Journal of Baghdad College of Dentistry
Issue
Vol. 24, Issue 4 (31 Dec. 2012), pp.62-66, 5 p.
Publisher
University of Baghdad College of Dentistry
Publication Date
2012-12-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Squamous cell carcinoma is a malignant neoplasm of stratified squamous Epithelium ; it is by far the most common malignant neoplasm of the oral cavity representing approximately 94 % of oral cancer.
It is capable of local destruction and invasion with distant metastasis.
This study evaluates the Immunohistochemical expression of TGF-β and MMP-2 as markers of invasion and metastasis of OSCC and their correlation with the tumor grade and stage and with each other. Materials and methods : Thirty blocks of OSCC were included in this study.
An immunohistochemical staining was performed using anti matrix metalloproteinase-2 and anti-transforming growth factor-β monoclonal antibodies. Results : Positive immunohistochemical expression of MMP-2 and TGF- β was found in (100 %) and (93.3 %) of the cases respectively.
No statistically significant correlation was found regarding either markers with respect to the tumor grade and stage .On the other hand a statistically significant correlation was found between the expressions of both markers (p = 0.036). Conclusions : TGF-β and MMP-2 immunoexpression showed no significant influence on tumor invasion and metastasis in relation to the tumor grade and stage.
While the significant correlation seen regarding the expression of both markers with each other, suggests their cooperative role in oral squamous cell carcinoma.
American Psychological Association (APA)
al-Qazzaz, Haydar H.& Sarkis, Sita A.. 2012. Immunohistochemical expression of TGF-β in relation to invasion potential evaluated by MMP-2 in oral squamous cell carcinoma. Journal of Baghdad College of Dentistry،Vol. 24, no. 4, pp.62-66.
https://search.emarefa.net/detail/BIM-324162
Modern Language Association (MLA)
al-Qazzaz, Haydar H.& Sarkis, Sita A.. Immunohistochemical expression of TGF-β in relation to invasion potential evaluated by MMP-2 in oral squamous cell carcinoma. Journal of Baghdad College of Dentistry Vol. 24, no. 4 (2012), pp.62-66.
https://search.emarefa.net/detail/BIM-324162
American Medical Association (AMA)
al-Qazzaz, Haydar H.& Sarkis, Sita A.. Immunohistochemical expression of TGF-β in relation to invasion potential evaluated by MMP-2 in oral squamous cell carcinoma. Journal of Baghdad College of Dentistry. 2012. Vol. 24, no. 4, pp.62-66.
https://search.emarefa.net/detail/BIM-324162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 65-66
Record ID
BIM-324162