The effect of sulcular injection of meloxicom on biochemical parameter of rabbit

Abstract EN

Background : Meloxicam is an NSAID of the oxicam class that acts by inhibiting prostaglandin synthesis and inducible COX-2, thereby exerting anti-inflammatory effect.

This study aimed to evaluate the level of alkaline phosphetase and high sensitivity C - reactive protein as response to sulcular injection of meloxicom using a rabbit model. Material and method : Forty five male rabbits of the same species were divided into three groups.

Group 1 which included 20 rabbits that injected with meloxicon in a dose equal to the human therapeutic dose / kg.

Group 2 which included 15 rabbits that injected with normal saline.

Group 3 which included 10 rabbits used as control group.

Five ml of blood was collected from the rabbits ear vien for biochemical analysis at deferent time interval.

Biochemical analysis included alkaline phosphetase (ALP) which analyzed by using Biolabo kit and High sensitivity C- reactive protein (hs- CRP) was measured using ELISA technique. Results : The result showed that the level of ALP after 1 day of sulcular injection in group 1 was 101.25 then it was decrease to 97.50 after 14 days while mean of ALP in group 2 was 70.33 After 1 day of injection and reach to 74.67 After 14 days and this almost near to the mean value of control group Statistic description of hs-CRP for group 1 was decreased.

The mean value from 11.617 after 1 day to 3.639 after 14 days.

For group 2 also there was decreased in the mean from 11.556 after 1 day to 3.536 after 14 days, while for the control group the mean value was 3.170. Conclusions : The sulcular injection of NSAIDs seems to be of particular interest.

This may help to further reduce adverse systemic effects of NSAIDs in treatment of periodontal disease safely.