Correlation between biochemical analysis and periodontal health status and tooth loss in chronic renal failure patients

Abstract EN

Background : Periodontal disease is a chronic bacterial infection that affects the gingiva and bone supporting the teeth.

The chronic renal failure is one of the serious systemic diseases.

It causes general systemic changes which reflect themselves on the oral cavity components.

The aims of this study is to determine and compare the periodontal clinical parameters and tooth loss between renal failure patients under hemodialysis and healthy individuals, to determine and compare the levels of C-reactive protein and albumin in saliva and serum between these two groups and to correlate the biochemical parameters with the clinical parameters for the renal failure patients. Materials and Methods : Sample population consisted of (100) individuals.

Males and females were included in this study aged from 45-55 years old.

The human sample divided into two main groups ; study and control groups.

The study group subdivided into hepatitis positive and negative subgroups.

Sample recruited for study were 73 patients attending the Artificial Kidney Centers in Baghdad city, all were under hemodialysis.

The control group consisted of 27 healthy individuals no history of any systemic disease.

All the clinical parameters were tested for both groups together with the levels of C-reactive protein and albumin in saliva and serum. Results : The statistical analysis revealed highly significant differences between the study and control groups for all the clinical parameters and highly significant differences between the study and control groups when comparing the levels of albumin and C - reactive protein in saliva and serum.

Non-significant differences were found when comparing males and females for each group for both clinical and biochemical parameters.

But highly significant differences were illustrated when comparing between hepatitis +ve and –ve patients in the study group for all the parameters.

Few strong correlations were revealed between the clinical and biochemical parameters; however, most of the correlations had confidence levels more than 75% which could have clinical significance. Conclusions : The study group had worse periodontal health status than the control group.

Also, there was a weak correlation between the clinical and biochemical parameters but with some interested numerical differences.