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Relationship between radiosensitivity and normal tissue complications in saudi cancer patients treated with radiotherapy
Joint Authors
al-Sibai, Midhat M.
al-Subayh, Ghazi
al-Rajihi, Nasir
Allam, Ayman
al-Buhayri, Munirah
al-Harbi, Najla
Khafajah, Yasir
al-Sabil, Muhammad
al-Shabanah, Muhammad K.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 16, Issue 4 (31 Dec. 2004), pp.216-223, 8 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2004-12-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
Purpose : To assess the variations in radiosensitivity, its relationship with clinical complications and the potential application of predictive testing in Saudi radiotherapy patients.
Materials and Methods : Forty-one patients included in this study, during (17) or after (24) their radiation treatment for head and neck (26), breast (9), gynecological (3) or other (3) cancer.
Skin fibroblasts were established and radiosensitivity was measured.
The surviving fraction at 2 Gy (SF2) was calculated and compared to the maximum grade of acute (erythema, desquamation, mucositis, ulceration) and late reactions (atrophy, fibrosis, xerostomia, telangiectasia).
Follow-up ranged between 12 and 178 months (median 30).
Results : SF2 ranged between 0.16 and 0.56 (mean 0.34).
The inter-patients coefficient of variation (CV) was 26%.
The intra-patient CV was 18%.
There was a statistically significant correlation between fibroblasts SF2 and the maximum grade of late (p = 0.012; 40 patients), but not acute complications (p = 0.70; 36 patients).
There was no correlation between acute and late reactions (p > 0.05; 34 patients).
Conclusions : These data revealed wide variations in cellular radiosensitivity that correlated with late reactions to radiation treatment.
Radiotherapy patients, particularly those at risk to sustain severe complications may well benefit from individualizing the doses prescription.
However, a predictive test alternative to SF2 is required.
American Psychological Association (APA)
al-Subayh, Ghazi& al-Sibai, Midhat M.& al-Rajihi, Nasir& Allam, Ayman& al-Buhayri, Munirah& al-Harbi, Najla…[et al.]. 2004. Relationship between radiosensitivity and normal tissue complications in saudi cancer patients treated with radiotherapy. Journal of the Egyptian National Cancer Institute،Vol. 16, no. 4, pp.216-223.
https://search.emarefa.net/detail/BIM-32450
Modern Language Association (MLA)
al-Subayh, Ghazi…[et al.]. Relationship between radiosensitivity and normal tissue complications in saudi cancer patients treated with radiotherapy. Journal of the Egyptian National Cancer Institute Vol. 16, no. 4 (Dec. 2004), pp.216-223.
https://search.emarefa.net/detail/BIM-32450
American Medical Association (AMA)
al-Subayh, Ghazi& al-Sibai, Midhat M.& al-Rajihi, Nasir& Allam, Ayman& al-Buhayri, Munirah& al-Harbi, Najla…[et al.]. Relationship between radiosensitivity and normal tissue complications in saudi cancer patients treated with radiotherapy. Journal of the Egyptian National Cancer Institute. 2004. Vol. 16, no. 4, pp.216-223.
https://search.emarefa.net/detail/BIM-32450
Data Type
Journal Articles
Language
English
Notes
IIncludes bibliographical references : p. 222-223
Record ID
BIM-32450