Prognostic value of microvessel density, matrix metalloproteinase-9 and p53 protein expression in esophageal cancer
Joint Authors
Abd al-Nur, Muhammad Fathi
al-Shahhat, Muhammad
Lutfi, Mahmud
Fahmi, Lamya
al-Kenawy, Ayman al-Meghawry
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 16, Issue 4 (31 Dec. 2004), pp.224-230, 7 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2004-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background : Worldwide, esophageal carcinoma is one of the most aggressive cancers.
It is relatively common in many countries and characterized by poor prognosis and rapid clinical progression.
Purpose : In this study, we aimed to evaluate the role of CD34, the marker of vascular endothelial cells, MMP- 9 (matrix metalloproteinase type 9) and p53 in esophageal carcinoma.
Materials and Methods : Forty-four archival tissue specimens, 38 cases with esophageal carcinoma and six cases with normal mucosa, were immunohistochemically stained with monoclonal antibodies against CD34, MMP- 9 and p53.
In addition, flow cytometric DNA analysis was carried out for patients and controls.
Results : The results showed that the DNA content was diploid in all normal esophageal mucosa, whereas aneuploidy was detected in twenty cases (52.6%) out of 38.
The thirty-eight cases showed positive expression of CD34 antigen.
The expression of MMP-9 was identified mainly in the cytoplasm in most of cancer cells in 27 cases (71%) out of 38.
On the other hand, 28 (73.7%) out of 38 were positive for p53 expression.
There was a statistical significance for CD34, MMP-9 and p53 expressions with tumor stage.
Micro vessel density in patients with highly positive staining for MMP-9 was higher than in those with negative and weak staining for MMP-9 (p= 0.002).
Conclusion : Our data suggest that the expression of CD34 and MMP-9 is associated with tumor progression and possibly seems to be valuable markers and could offer additional information about the aggressiveness and activity of esophageal carcinoma lesions.
American Psychological Association (APA)
al-Shahhat, Muhammad& Lutfi, Mahmud& Fahmi, Lamya& Abd al-Nur, Muhammad Fathi& al-Kenawy, Ayman al-Meghawry. 2004. Prognostic value of microvessel density, matrix metalloproteinase-9 and p53 protein expression in esophageal cancer. Journal of the Egyptian National Cancer Institute،Vol. 16, no. 4, pp.224-230.
https://search.emarefa.net/detail/BIM-32452
Modern Language Association (MLA)
al-Shahhat, Muhammad…[et al.]. Prognostic value of microvessel density, matrix metalloproteinase-9 and p53 protein expression in esophageal cancer. Journal of the Egyptian National Cancer Institute Vol. 16, no. 4 (Dec. 2004), pp.224-230.
https://search.emarefa.net/detail/BIM-32452
American Medical Association (AMA)
al-Shahhat, Muhammad& Lutfi, Mahmud& Fahmi, Lamya& Abd al-Nur, Muhammad Fathi& al-Kenawy, Ayman al-Meghawry. Prognostic value of microvessel density, matrix metalloproteinase-9 and p53 protein expression in esophageal cancer. Journal of the Egyptian National Cancer Institute. 2004. Vol. 16, no. 4, pp.224-230.
https://search.emarefa.net/detail/BIM-32452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical References: p p 229-230
Record ID
BIM-32452