Pathological and biochemical study on the albino rat treated with curcuma longa induced atherosclerosis by H2O2

Abstract EN

This study was conducted to determined the effect of curcuma longa (C-longa) as antioxidant and antiatherogenic in male rats after treated with 0.5 % hydrogen peroxide (H2O2) in order to induced atherosclerosis oxidative stress have been investigated via estimation of Malondialdehyde (MDA) and Glutathione (GSH) in aorta and liver tissues as indirect lipid peroxidation index.

The results elucidate significant elevation in GSH concentration parallel significant reduction in MDA concentration in aorta and liver tissues as well as increase in HDL-C and decrease in LDL-C in serum of male rats treated with Clonga and H2O2.

Histological finding resulted less improvement in histological picture, reduction in lipid vacuoles in both internal and medial layers associated with proliferation of vascular smooth muscle cells (VSMC) but it not reach to normal tissue.